Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

Age-associated changes in CD4 T-cell functionality have been linked to chronic inflammation and decreased immunity. However, a detailed characterization of CD4 T cell phenotypes that could explain these dysregulated functional properties is lacking. We used single-cell RNA sequencing and multidimens...

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Detalles Bibliográficos
Autores principales: Elyahu, Yehezqel, Hekselman, Idan, Eizenberg-Magar, Inbal, Berner, Omer, Strominger, Itai, Schiller, Maya, Mittal, Kritika, Nemirovsky, Anna, Eremenko, Ekaterina, Vital, Assaf, Simonovsky, Eyal, Chalifa-Caspi, Vered, Friedman, Nir, Yeger-Lotem, Esti, Monsonego, Alon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703865/
https://www.ncbi.nlm.nih.gov/pubmed/31457092
http://dx.doi.org/10.1126/sciadv.aaw8330

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