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Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer–mediated autoimmune diabetes

Human leukocyte antigen (HLA)–DQ8 transdimer (HLA-DQA1*0501/DQB1*0302) confers exceptionally high risk in autoimmune diabetes. However, little is known about HLA-DQ8 transdimer–restricted CD4 T cell recognition, an event crucial for triggering HLA-DQ8 transdimer–specific anti-islet immunity. Here, w...

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Detalles Bibliográficos
Autores principales:	Chow, I-Ting, Gates, Theresa J., Papadopoulos, George K., Moustakas, Antonis K., Kolawole, Elizabeth M., Notturno, Richard J., McGinty, John W., Torres-Chinn, Nadia, James, Eddie A., Greenbaum, Carla, Nepom, Gerald T., Evavold, Brian D., Kwok, William W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703875/ https://www.ncbi.nlm.nih.gov/pubmed/31457096 http://dx.doi.org/10.1126/sciadv.aaw9336

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