The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis

The tumor necrosis factor receptor superfamily member HVEM is one of the most frequently mutated surface proteins in germinal center (GC)-derived B cell lymphomas. We found that HVEM deficiency increased B cell competitiveness during pre-GC and GC responses. The immunoglobulin (Ig) superfamily prote...

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Detalles Bibliográficos
Autores principales: Mintz, Michelle A., Felce, James H., Chou, Marissa Y., Mayya, Viveka, Xu, Ying, Shui, Jr-Wen, An, Jinping, Li, Zhongmei, Marson, Alexander, Okada, Takaharu, Ware, Carl F., Kronenberg, Mitchell, Dustin, Michael L., Cyster, Jason G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703922/
https://www.ncbi.nlm.nih.gov/pubmed/31204070
http://dx.doi.org/10.1016/j.immuni.2019.05.022

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