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Altered neural oscillations within and between sensorimotor cortex and parietal cortex in chronic jaw pain

Pain perception is associated with priming of the motor system and the orienting of attention in healthy adults. These processes correspond with decreases in alpha and beta power in the sensorimotor and parietal cortices. The goal of the present study was to determine whether these findings extend t...

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Autores principales: Wang, Wei-en, Roy, Arnab, Misra, Gaurav, Ho, Rachel L.M., Ribeiro-Dasilva, Margarete C., Fillingim, Roger B., Coombes, Stephen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704052/
https://www.ncbi.nlm.nih.gov/pubmed/31412309
http://dx.doi.org/10.1016/j.nicl.2019.101964
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author Wang, Wei-en
Roy, Arnab
Misra, Gaurav
Ho, Rachel L.M.
Ribeiro-Dasilva, Margarete C.
Fillingim, Roger B.
Coombes, Stephen A.
author_facet Wang, Wei-en
Roy, Arnab
Misra, Gaurav
Ho, Rachel L.M.
Ribeiro-Dasilva, Margarete C.
Fillingim, Roger B.
Coombes, Stephen A.
author_sort Wang, Wei-en
collection PubMed
description Pain perception is associated with priming of the motor system and the orienting of attention in healthy adults. These processes correspond with decreases in alpha and beta power in the sensorimotor and parietal cortices. The goal of the present study was to determine whether these findings extend to individuals with chronic pain. Individuals with chronic jaw pain and pain-free controls anticipated and experienced a low pain or a moderate pain-eliciting heat stimulus. Although stimuli were calibrated for each subject, stimulus temperature was not different between groups. High-density EEG data were collected during the anticipation and heat stimulation periods and were analyzed using independent component analyses, EEG source localization, and measure projection analyses. Direct directed transfer function was also estimated to identify frequency specific effective connectivity between regions. Between group differences were most evident during the heat stimulation period. We report three novel findings. First, the chronic jaw pain group had a relative increase in alpha and beta power and a relative decrease in theta and gamma power in sensorimotor cortex. Second, the chronic jaw pain group had a relative increase in power in the alpha and beta bands in parietal cortex. Third, the chronic jaw pain group had less connectivity strength in the beta and gamma bands between sensorimotor cortex and parietal cortex. Our findings show that the effect of chronic pain attenuates rather than magnifies neural responses to heat stimuli. We interpret these findings in the context of system-level changes in intrinsic sensorimotor and attentional circuits in chronic pain.
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spelling pubmed-67040522019-08-26 Altered neural oscillations within and between sensorimotor cortex and parietal cortex in chronic jaw pain Wang, Wei-en Roy, Arnab Misra, Gaurav Ho, Rachel L.M. Ribeiro-Dasilva, Margarete C. Fillingim, Roger B. Coombes, Stephen A. Neuroimage Clin Regular Article Pain perception is associated with priming of the motor system and the orienting of attention in healthy adults. These processes correspond with decreases in alpha and beta power in the sensorimotor and parietal cortices. The goal of the present study was to determine whether these findings extend to individuals with chronic pain. Individuals with chronic jaw pain and pain-free controls anticipated and experienced a low pain or a moderate pain-eliciting heat stimulus. Although stimuli were calibrated for each subject, stimulus temperature was not different between groups. High-density EEG data were collected during the anticipation and heat stimulation periods and were analyzed using independent component analyses, EEG source localization, and measure projection analyses. Direct directed transfer function was also estimated to identify frequency specific effective connectivity between regions. Between group differences were most evident during the heat stimulation period. We report three novel findings. First, the chronic jaw pain group had a relative increase in alpha and beta power and a relative decrease in theta and gamma power in sensorimotor cortex. Second, the chronic jaw pain group had a relative increase in power in the alpha and beta bands in parietal cortex. Third, the chronic jaw pain group had less connectivity strength in the beta and gamma bands between sensorimotor cortex and parietal cortex. Our findings show that the effect of chronic pain attenuates rather than magnifies neural responses to heat stimuli. We interpret these findings in the context of system-level changes in intrinsic sensorimotor and attentional circuits in chronic pain. Elsevier 2019-07-31 /pmc/articles/PMC6704052/ /pubmed/31412309 http://dx.doi.org/10.1016/j.nicl.2019.101964 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Wang, Wei-en
Roy, Arnab
Misra, Gaurav
Ho, Rachel L.M.
Ribeiro-Dasilva, Margarete C.
Fillingim, Roger B.
Coombes, Stephen A.
Altered neural oscillations within and between sensorimotor cortex and parietal cortex in chronic jaw pain
title Altered neural oscillations within and between sensorimotor cortex and parietal cortex in chronic jaw pain
title_full Altered neural oscillations within and between sensorimotor cortex and parietal cortex in chronic jaw pain
title_fullStr Altered neural oscillations within and between sensorimotor cortex and parietal cortex in chronic jaw pain
title_full_unstemmed Altered neural oscillations within and between sensorimotor cortex and parietal cortex in chronic jaw pain
title_short Altered neural oscillations within and between sensorimotor cortex and parietal cortex in chronic jaw pain
title_sort altered neural oscillations within and between sensorimotor cortex and parietal cortex in chronic jaw pain
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704052/
https://www.ncbi.nlm.nih.gov/pubmed/31412309
http://dx.doi.org/10.1016/j.nicl.2019.101964
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