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Transient multimers modulate conformer abundances of prion protein monomer through conformational selection
Prions are known to be involved in neurodegenerative pathologies such as Creutzfeld-Jakob disease. Current models point to a molecular event which rely on a transmissible structural change that leads to the production of β-sheet-rich prion conformer (PrP(Sc)). PrP(Sc) itself has the capability to tr...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704068/ https://www.ncbi.nlm.nih.gov/pubmed/31434938 http://dx.doi.org/10.1038/s41598-019-48377-w |