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Catalytically Impaired TYK2 Variants are Protective Against Childhood- and Adult-Onset Systemic Lupus Erythematosus in Mexicans

Type I interferon (IFN-I) pathway plays a central role in the systemic lupus erythematosus (SLE) pathogenesis. Recent data suggest that SLE is associated with variants in IFN-I genes, such as tyrosine kinase 2 (TYK2), which is crucial in anti-viral immunity. Here, five TYK2 single nucleotide polymor...

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Detalles Bibliográficos
Autores principales:	Contreras-Cubas, Cecilia, García-Ortiz, Humberto, Velázquez-Cruz, Rafael, Barajas-Olmos, Francisco, Baca, Paulina, Martínez-Hernández, Angélica, Barbosa-Cobos, Rosa Elda, Ramírez-Bello, Julian, López-Hernández, Maria A., Svyryd, Yevgeniya, Mutchinick, Osvaldo M., Baca, Vicente, Orozco, Lorena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704113/ https://www.ncbi.nlm.nih.gov/pubmed/31434951 http://dx.doi.org/10.1038/s41598-019-48451-3

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