Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response

Autophagy cargo recognition and clearance are essential for intracellular protein quality control. SQSTM1/p62 sequesters intracellular aberrant proteins and mediates cargo delivery for their selective autophagic degradation. The formation of p62 non-membrane-bound liquid compartments is critical for...

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Detalles Bibliográficos
Autores principales: Yang, Yi, Willis, Thea L., Button, Robert W., Strang, Conor J., Fu, Yuhua, Wen, Xue, Grayson, Portia R. C., Evans, Tracey, Sipthorpe, Rebecca J., Roberts, Sheridan L., Hu, Bing, Zhang, Jianke, Lu, Boxun, Luo, Shouqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704147/
https://www.ncbi.nlm.nih.gov/pubmed/31434890
http://dx.doi.org/10.1038/s41467-019-11671-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704147/
https://www.ncbi.nlm.nih.gov/pubmed/31434890
http://dx.doi.org/10.1038/s41467-019-11671-2

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