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Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma

Kynurenine pathway (KP) activation by the enzymatic activity of indoleamine 2,3-dioxygenase1 (IDO1) and kynurenine (KYN) production represents an attractive target for reducing tumour progression and improving anti-tumour immunity in multiple cancers. However, immunomodulatory properties of other KP...

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Detalles Bibliográficos
Autores principales:	Rad Pour, Soudabeh, Morikawa, Hiromasa, Kiani, Narsis A., Yang, Muyi, Azimi, Alireza, Shafi, Gowhar, Shang, Mingmei, Baumgartner, Roland, Ketelhuth, Daniel F. J., Kamleh, Muhammad Anas, Wheelock, Craig E., Lundqvist, Andreas, Hansson, Johan, Tegnér, Jesper
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704156/ https://www.ncbi.nlm.nih.gov/pubmed/31434983 http://dx.doi.org/10.1038/s41598-019-48635-x

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