Structure-function relationship of an Urokinase Receptor-derived peptide which inhibits the Formyl Peptide Receptor type 1 activity

The interaction between the short 88Ser-Arg-Ser-Arg-Tyr92 sequence of the urokinase receptor (uPAR) and the formyl peptide receptor type 1 (FPR1) elicits cell migration. We generated the Ac-(D)-Tyr-(D)-Arg-Aib-(D)-Arg-NH2 (RI-3) peptide which inhibits the uPAR/FPR1 interaction, reducing migration of...

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Detalles Bibliográficos
Autores principales: Minopoli, Michele, Polo, Andrea, Ragone, Concetta, Ingangi, Vincenzo, Ciliberto, Gennaro, Pessi, Antonello, Sarno, Sabrina, Budillon, Alfredo, Costantini, Susan, Carriero, Maria Vincenza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704176/
https://www.ncbi.nlm.nih.gov/pubmed/31434916
http://dx.doi.org/10.1038/s41598-019-47900-3

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