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Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

High resolution structural information on amyloid fibrils is crucial for the understanding of their formation mechanisms and for the rational design of amyloid inhibitors in the context of protein misfolding diseases. The Src-homology 3 domain of phosphatidyl-inositol-3-kinase (PI3K-SH3) is a model...

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Detalles Bibliográficos
Autores principales:	Röder, Christine, Vettore, Nicola, Mangels, Lena N., Gremer, Lothar, Ravelli, Raimond B. G., Willbold, Dieter, Hoyer, Wolfgang, Buell, Alexander K., Schröder, Gunnar F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704188/ https://www.ncbi.nlm.nih.gov/pubmed/31434882 http://dx.doi.org/10.1038/s41467-019-11320-8

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