Cargando…

siRNA-Finder (si-Fi) Software for RNAi-Target Design and Off-Target Prediction

RNA interference (RNAi) is a technique used for transgene-mediated gene silencing based on the mechanism of posttranscriptional gene silencing (PTGS). PTGS is an ubiquitous basic biological phenomenon involved in the regulation of transcript abundance and plants’ immune response to viruses. PTGS als...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lück, Stefanie, Kreszies, Tino, Strickert, Marc, Schweizer, Patrick, Kuhlmann, Markus, Douchkov, Dimitar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Plant Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704232/ https://www.ncbi.nlm.nih.gov/pubmed/31475020 http://dx.doi.org/10.3389/fpls.2019.01023

Ejemplares similares

siRNA Specificity: RNAi Mechanisms and Strategies to Reduce Off-Target Effects
por: Neumeier, Julia, et al.
Publicado: (2021)

Optimal choice of functional and off-target effect-reduced siRNAs for RNAi therapeutics
por: Ui-Tei, Kumiko
Publicado: (2013)

Off-target effects of siRNA specific for GFP
por: Tschuch, Cordula, et al.
Publicado: (2008)

siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect
por: Naito, Yuki, et al.
Publicado: (2009)

RNAiAtlas: a database for RNAi (siRNA) libraries and their specificity
por: Mazur, Sławek, et al.
Publicado: (2012)

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
por: Davis, Mark E., et al.
Publicado: (2010)

Targeted CRM197-PEG-PEI/siRNA Complexes for Therapeutic RNAi in Glioblastoma
por: Höbel, Sabrina, et al.
Publicado: (2011)

RNAi therapeutics: Can siRNAs conquer SARS?
por: Chang, Z, et al.
Publicado: (2005)

Targeted Delivery of siRNA
por: Oliveira, Sabrina, et al.
Publicado: (2006)

siPools: highly complex but accurately defined siRNA pools eliminate off-target effects
por: Hannus, Michael, et al.
Publicado: (2014)

Designer siRNAs to overcome the challenges from the RNAi pathway
por: Jayasena, Sumedha D
Publicado: (2005)

siRNA Design Software for a Target Gene-Specific RNA Interference
por: Naito, Yuki, et al.
Publicado: (2012)

Minimizing off-target effects by using diced siRNAs for RNA interference
por: Myers, Jason W, et al.
Publicado: (2006)

Whole-Genome Thermodynamic Analysis Reduces siRNA Off-Target Effects
por: Chen, Xi, et al.
Publicado: (2013)

siRNAs Induce Efficient RNAi Response in Bombyx mori Embryos
por: Yamaguchi, Junichi, et al.
Publicado: (2011)

Utilizing Selected Di- and Trinucleotides of siRNA to Predict RNAi Activity
por: Han, Ye, et al.
Publicado: (2017)

siAbasic: a comprehensive database for potent siRNA-6Ø sequences without off-target effects
por: Park, Jongyeun, et al.
Publicado: (2018)

siRNA Off-Target Effects Can Be Reduced at Concentrations That Match Their Individual Potency
por: Caffrey, Daniel R., et al.
Publicado: (2011)

Off-Target Effect of Endogenous siRNA Derived from RMRP in Human Cells
por: Maida, Yoshiko, et al.
Publicado: (2013)

Rationally designed siRNAs without miRNA-like off-target repression
por: Seok, Heeyoung, et al.
Publicado: (2016)

“Macrobot”: An Automated Segmentation-Based System for Powdery Mildew Disease Quantification
por: Lück, Stefanie, et al.
Publicado: (2020)

The siRNA Non-seed Region and Its Target Sequences Are Auxiliary Determinants of Off-Target Effects
por: Kamola, Piotr J., et al.
Publicado: (2015)

siRNA Targeting and Treatment of Gastrointestinal Diseases
por: Chevalier, Rachel
Publicado: (2019)

Multiplexing siRNAs to compress RNAi-based screen size in human cells
por: Martin, Scott E., et al.
Publicado: (2007)

Essential Notes Regarding the Design of Functional siRNAs for Efficient Mammalian RNAi
por: Ui-Tei, Kumiko, et al.
Publicado: (2006)

Mosquito and Drosophila entomobirnaviruses suppress dsRNA- and siRNA-induced RNAi
por: van Cleef, Koen W.R., et al.
Publicado: (2014)

RNAi mechanisms in Huntington’s disease therapy: siRNA versus shRNA
por: Aguiar, Sebastian, et al.
Publicado: (2017)

siRNA-mediated off-target gene silencing triggered by a 7 nt complementation
por: Lin, Xiaoyu, et al.
Publicado: (2005)

Detecting microRNA binding and siRNA off-target effects from expression data
por: van Dongen, Stijn, et al.
Publicado: (2008)

siRNA off-target effects in genome-wide screens identify signaling pathway members
por: Buehler, Eugen, et al.
Publicado: (2012)

siRNAs with decreased off-target effect facilitate the identification of essential genes in cancer cells
por: Li, Chunyan, et al.
Publicado: (2015)

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
por: Janas, Maja M., et al.
Publicado: (2018)

Learning signaling networks from combinatorial perturbations by exploiting siRNA off-target effects
por: Tiuryn, Jerzy, et al.
Publicado: (2019)

Ocular neuroprotection by siRNA targeting caspase-2
por: Ahmed, Z, et al.
Publicado: (2011)

Targeted Delivery of siRNA Therapeutics to Malignant Tumors
por: Leng, Qixin, et al.
Publicado: (2017)

A ribonucleoprotein octamer for targeted siRNA delivery
por: Tai, Wanyi, et al.
Publicado: (2018)

Targeted siRNA Nanoparticles for Mammary Carcinoma Therapy
por: Ben-David-Naim, Meital, et al.
Publicado: (2019)

In Silico Design of siRNAs Targeting Existing and Future Respiratory Viruses with VirusSi
por: Zhang, Dingyao, et al.
Publicado: (2020)

Delivery Systems for the Direct Application of siRNAs to Induce RNA Interference (RNAi) In Vivo
por: Aigner, Achim
Publicado: (2006)

Integrated siRNA design based on surveying of features associated with high RNAi effectiveness
por: Gong, Wuming, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_3nrlvue5bqbk8ktn6954gm9hq9