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Transgenic overexpression of polysialyltransferase ST8SiaIV under the control of a neuron-specific promoter does not affect brain development but impairs exploratory behavior

A large body of the literature has demonstrated that the polysialic acid (polySia) modification of the neural cell adhesion molecule (NCAM) is a key regulator of cellular interactions during brain development, maintenance and plasticity. To properly fulfill these functions, polySia concentration has...

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Detalles Bibliográficos
Autores principales:	Fewou, Simon Ngamli, Röckle, Iris, Hildebrandt, Herbert, Eckhardt, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704368/ https://www.ncbi.nlm.nih.gov/pubmed/31147692 http://dx.doi.org/10.1093/glycob/cwz040

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