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Synthesis and pharmacological characterization of ethylenediamine synthetic opioids in human μ‐opiate receptor 1 (OPRM1) expressing cells

Opioids are powerful analgesics acting via the human μ‐opiate receptor (hMOR). Opioid use is associated with adverse effects such as tolerance, addiction, respiratory depression, and constipation. Two synthetic opioids, AH‐7921 and U‐47700 that were developed in the 1970s but never marketed, have re...

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Detalles Bibliográficos
Autores principales:	Hsu, Tom, Mallareddy, Jayapal R., Yoshida, Kayla, Bustamante, Vincent, Lee, Tim, Krstenansky, John L., Zambon, Alexander C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704399/ https://www.ncbi.nlm.nih.gov/pubmed/31463067 http://dx.doi.org/10.1002/prp2.511

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