Development of coupling controlled polymerizations by adapter-ligation in mate-pair sequencing for detection of various genomic variants in one single assay

The diversity of disease presentations warrants one single assay for detection and delineation of various genomic disorders. Herein, we describe a gel-free and biotin-capture-free mate-pair method through coupling Controlled Polymerizations by Adapter-Ligation (CP-AL). We first demonstrated the feas...

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Detalles Bibliográficos
Autores principales: Dong, Zirui, Zhao, Xia, Li, Qiaoling, Yang, Zhenjun, Xi, Yang, Alexeev, Andrei, Shen, Hanjie, Wang, Ou, Ruan, Jie, Ren, Han, Wei, Hanmin, Qi, Xiaojuan, Li, Jiguang, Zhu, Xiaofan, Zhang, Yanyan, Dai, Peng, Kong, Xiangdong, Kirkconnell, Killeen, Alferov, Oleg, Giles, Shane, Yamtich, Jennifer, Kermani, Bahram G, Dong, Chao, Liu, Pengjuan, Mi, Zilan, Zhang, Wenwei, Xu, Xun, Drmanac, Radoje, Choy, Kwong Wai, Jiang, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704401/
https://www.ncbi.nlm.nih.gov/pubmed/31173071
http://dx.doi.org/10.1093/dnares/dsz011

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