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Glycated hemoglobin versus oral glucose tolerance test in the identification of subjects with prediabetes in Qatari population

BACKGROUND: Subjects with prediabetes are at increased risk of future T2DM and cardiovascular disease (CVD) compared to NGT individuals. The OGTT (FPG = 100–125 and 2 h-PG = 140–199 mg/dl) and HbA1c 5.7–6.4% have been used to diagnose subjects with prediabetes. In the present study, we compared the...

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Autores principales: Iskandar, Saadallah, Migahid, Ayman, Kamal, Dalia, Megahed, Osama, DeFronzo, Ralph A., Zirie, Mahmoud, Jayyousi, Amin, Al Jaidah, Mahmood, Abdul-Ghani, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704621/
https://www.ncbi.nlm.nih.gov/pubmed/31438915
http://dx.doi.org/10.1186/s12902-019-0412-1
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author Iskandar, Saadallah
Migahid, Ayman
Kamal, Dalia
Megahed, Osama
DeFronzo, Ralph A.
Zirie, Mahmoud
Jayyousi, Amin
Al Jaidah, Mahmood
Abdul-Ghani, Muhammad
author_facet Iskandar, Saadallah
Migahid, Ayman
Kamal, Dalia
Megahed, Osama
DeFronzo, Ralph A.
Zirie, Mahmoud
Jayyousi, Amin
Al Jaidah, Mahmood
Abdul-Ghani, Muhammad
author_sort Iskandar, Saadallah
collection PubMed
description BACKGROUND: Subjects with prediabetes are at increased risk of future T2DM and cardiovascular disease (CVD) compared to NGT individuals. The OGTT (FPG = 100–125 and 2 h-PG = 140–199 mg/dl) and HbA1c 5.7–6.4% have been used to diagnose subjects with prediabetes. In the present study, we compared the ability of the OGTT and HbA1c to identify Qatari subjects with prediabetes. METHODS: Four hundred forty six subjects without a history of T2DM received 75-g OGTT and measurement of HbA1c. The incidence of prediabetes in this cohort according to OGTT criteria was compared to that of HbA1c criteria. RESULTS: The agreement between the OGTT and HbA1c in identifying subjects with prediabetes in Qatari subjects was poor, though significant (k = 015, p < 0.0001). Only 56% of participants had prediabetes or NGT according to OGTT and HbA1c. The disagreement between OGTT and HbA1c in diagnosing prediabetes was primarily due to low sensitivity of HbA1c. Moreover, subjects with prediabetes diagnosed with the OGTT have more severe metabolic profile than prediabetic subjects diagnosed with HbA1c. Lastly, more subjects with the metabolic syndrome were identified with OGTT (60%) criteria than with the HbA1c (49%), p < 0.0001. CONCLUSION: These results demonstrate subjects with prediabetes diagnosed with OGTT have more severe metabolic risk than those diagnosed with HbA1c, and more likely to have greater risk of progression to T2DM.
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spelling pubmed-67046212019-08-22 Glycated hemoglobin versus oral glucose tolerance test in the identification of subjects with prediabetes in Qatari population Iskandar, Saadallah Migahid, Ayman Kamal, Dalia Megahed, Osama DeFronzo, Ralph A. Zirie, Mahmoud Jayyousi, Amin Al Jaidah, Mahmood Abdul-Ghani, Muhammad BMC Endocr Disord Research Article BACKGROUND: Subjects with prediabetes are at increased risk of future T2DM and cardiovascular disease (CVD) compared to NGT individuals. The OGTT (FPG = 100–125 and 2 h-PG = 140–199 mg/dl) and HbA1c 5.7–6.4% have been used to diagnose subjects with prediabetes. In the present study, we compared the ability of the OGTT and HbA1c to identify Qatari subjects with prediabetes. METHODS: Four hundred forty six subjects without a history of T2DM received 75-g OGTT and measurement of HbA1c. The incidence of prediabetes in this cohort according to OGTT criteria was compared to that of HbA1c criteria. RESULTS: The agreement between the OGTT and HbA1c in identifying subjects with prediabetes in Qatari subjects was poor, though significant (k = 015, p < 0.0001). Only 56% of participants had prediabetes or NGT according to OGTT and HbA1c. The disagreement between OGTT and HbA1c in diagnosing prediabetes was primarily due to low sensitivity of HbA1c. Moreover, subjects with prediabetes diagnosed with the OGTT have more severe metabolic profile than prediabetic subjects diagnosed with HbA1c. Lastly, more subjects with the metabolic syndrome were identified with OGTT (60%) criteria than with the HbA1c (49%), p < 0.0001. CONCLUSION: These results demonstrate subjects with prediabetes diagnosed with OGTT have more severe metabolic risk than those diagnosed with HbA1c, and more likely to have greater risk of progression to T2DM. BioMed Central 2019-08-22 /pmc/articles/PMC6704621/ /pubmed/31438915 http://dx.doi.org/10.1186/s12902-019-0412-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Iskandar, Saadallah
Migahid, Ayman
Kamal, Dalia
Megahed, Osama
DeFronzo, Ralph A.
Zirie, Mahmoud
Jayyousi, Amin
Al Jaidah, Mahmood
Abdul-Ghani, Muhammad
Glycated hemoglobin versus oral glucose tolerance test in the identification of subjects with prediabetes in Qatari population
title Glycated hemoglobin versus oral glucose tolerance test in the identification of subjects with prediabetes in Qatari population
title_full Glycated hemoglobin versus oral glucose tolerance test in the identification of subjects with prediabetes in Qatari population
title_fullStr Glycated hemoglobin versus oral glucose tolerance test in the identification of subjects with prediabetes in Qatari population
title_full_unstemmed Glycated hemoglobin versus oral glucose tolerance test in the identification of subjects with prediabetes in Qatari population
title_short Glycated hemoglobin versus oral glucose tolerance test in the identification of subjects with prediabetes in Qatari population
title_sort glycated hemoglobin versus oral glucose tolerance test in the identification of subjects with prediabetes in qatari population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704621/
https://www.ncbi.nlm.nih.gov/pubmed/31438915
http://dx.doi.org/10.1186/s12902-019-0412-1
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