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Topoisomerase inhibitors promote cancer cell motility via ROS-mediated activation of JAK2-STAT1-CXCL1 pathway

BACKGROUND: Topoisomerase inhibitors (TI) can inhibit cell proliferation by preventing DNA replication, stimulating DNA damage and inducing cell cycle arrest. Although these agents have been commonly used in the chemotherapy for the anti-proliferative effect, their impacts on the metastasis of cance...

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Detalles Bibliográficos
Autores principales:	Liu, Jiafei, Qu, Like, Meng, Lin, Shou, Chengchao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704639/ https://www.ncbi.nlm.nih.gov/pubmed/31438997 http://dx.doi.org/10.1186/s13046-019-1353-2

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