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Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1

BACKGROUND: Arachidonic acid (AA) metabolic enzymes including cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1) and cytochrome P450 (CYP) 4A11 play important roles in glioma angiogenesis. Thus, there is an urgent need to identify the underlying mechanisms and develop strategi...

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Detalles Bibliográficos
Autores principales:	Wang, Chenlong, Chen, Yaxin, Wang, Yang, Liu, Xiaoxiao, Liu, Yanzhuo, Li, Ying, Chen, Honglei, Fan, Chengpeng, Wu, Dongfang, Yang, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704644/ https://www.ncbi.nlm.nih.gov/pubmed/31438982 http://dx.doi.org/10.1186/s13046-019-1361-2

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