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Sex-specific association of metabolic risk factors with brain ischemic lesions by severity and location

BACKGROUND: Males and females exhibit significant differences in metabolism and in brain ischemic stroke and different features of brain ischemic lesions are related to different health outcomes. It is critical to understand sex differences in their associations to optimize prevention and interventi...

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Autores principales: Zeng, Hailuan, Shi, Weibin, Jiang, Wenhai, Rao, Shengxiang, Huang, Beijian, Yan, Hongmei, Gao, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704651/
https://www.ncbi.nlm.nih.gov/pubmed/31439027
http://dx.doi.org/10.1186/s13293-019-0254-6
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author Zeng, Hailuan
Shi, Weibin
Jiang, Wenhai
Rao, Shengxiang
Huang, Beijian
Yan, Hongmei
Gao, Xin
author_facet Zeng, Hailuan
Shi, Weibin
Jiang, Wenhai
Rao, Shengxiang
Huang, Beijian
Yan, Hongmei
Gao, Xin
author_sort Zeng, Hailuan
collection PubMed
description BACKGROUND: Males and females exhibit significant differences in metabolism and in brain ischemic stroke and different features of brain ischemic lesions are related to different health outcomes. It is critical to understand sex differences in their associations to optimize prevention and intervention for both sexes. We aimed to investigate the sex-specific association of metabolic risk factors with brain ischemic lesions by severity and location. METHODS: Five thousand seven hundred ninety-one participants who underwent comprehensive health examinations between Jan. 1, 2017, and Dec. 31, 2017, were enrolled. Clinical and laboratory data about metabolic risk factors were obtained. Brain ischemic lesions were further categorized by severity (mild ischemic lesions or severe infarct lesions) and location (strictly lobar or deep brain/infratentorial areas) based on brain magnetic resonance imaging reports. Sex- and age-specific detected rates were calculated, and generalized linear models and multinomial logistic regression were used to analyze the associations between metabolic risk factors and the presence, severity, and location of ischemic lesions stratified by sex. RESULTS: A total of 2712 (46.8%) participants had at least one brain ischemic lesions. Age (adjusted OR, 1.10 [1.10–1.11], p < 0.001) and hypertension (adjusted OR, 1.42 [1.22–1.64], p < 0.001) were generally associated with higher risks of brain ischemia in both sexes. Metabolic syndrome was associated with greater adjusted ORs for brain ischemia with different severity and location in men (adjusted ORs between 1.23 and 1.49) but not in women. Overweight and obesity were related to lesions located strictly in lobar in men (adjusted OR, 1.23 and 1.33, respectively) and lesions located in deep brain/infratentorial areas in women (adjusted OR, 1.57 and 2.26, respectively). CONCLUSIONS: Metabolic syndrome was associated with brain ischemic lesions in men but not in women. Higher body mass index was related to ischemic lesions located in lobar in men and in deep brain/infratentorial areas in women. Its mechanisms remain to be further investigated.
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spelling pubmed-67046512019-08-22 Sex-specific association of metabolic risk factors with brain ischemic lesions by severity and location Zeng, Hailuan Shi, Weibin Jiang, Wenhai Rao, Shengxiang Huang, Beijian Yan, Hongmei Gao, Xin Biol Sex Differ Research BACKGROUND: Males and females exhibit significant differences in metabolism and in brain ischemic stroke and different features of brain ischemic lesions are related to different health outcomes. It is critical to understand sex differences in their associations to optimize prevention and intervention for both sexes. We aimed to investigate the sex-specific association of metabolic risk factors with brain ischemic lesions by severity and location. METHODS: Five thousand seven hundred ninety-one participants who underwent comprehensive health examinations between Jan. 1, 2017, and Dec. 31, 2017, were enrolled. Clinical and laboratory data about metabolic risk factors were obtained. Brain ischemic lesions were further categorized by severity (mild ischemic lesions or severe infarct lesions) and location (strictly lobar or deep brain/infratentorial areas) based on brain magnetic resonance imaging reports. Sex- and age-specific detected rates were calculated, and generalized linear models and multinomial logistic regression were used to analyze the associations between metabolic risk factors and the presence, severity, and location of ischemic lesions stratified by sex. RESULTS: A total of 2712 (46.8%) participants had at least one brain ischemic lesions. Age (adjusted OR, 1.10 [1.10–1.11], p < 0.001) and hypertension (adjusted OR, 1.42 [1.22–1.64], p < 0.001) were generally associated with higher risks of brain ischemia in both sexes. Metabolic syndrome was associated with greater adjusted ORs for brain ischemia with different severity and location in men (adjusted ORs between 1.23 and 1.49) but not in women. Overweight and obesity were related to lesions located strictly in lobar in men (adjusted OR, 1.23 and 1.33, respectively) and lesions located in deep brain/infratentorial areas in women (adjusted OR, 1.57 and 2.26, respectively). CONCLUSIONS: Metabolic syndrome was associated with brain ischemic lesions in men but not in women. Higher body mass index was related to ischemic lesions located in lobar in men and in deep brain/infratentorial areas in women. Its mechanisms remain to be further investigated. BioMed Central 2019-08-22 /pmc/articles/PMC6704651/ /pubmed/31439027 http://dx.doi.org/10.1186/s13293-019-0254-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Zeng, Hailuan
Shi, Weibin
Jiang, Wenhai
Rao, Shengxiang
Huang, Beijian
Yan, Hongmei
Gao, Xin
Sex-specific association of metabolic risk factors with brain ischemic lesions by severity and location
title Sex-specific association of metabolic risk factors with brain ischemic lesions by severity and location
title_full Sex-specific association of metabolic risk factors with brain ischemic lesions by severity and location
title_fullStr Sex-specific association of metabolic risk factors with brain ischemic lesions by severity and location
title_full_unstemmed Sex-specific association of metabolic risk factors with brain ischemic lesions by severity and location
title_short Sex-specific association of metabolic risk factors with brain ischemic lesions by severity and location
title_sort sex-specific association of metabolic risk factors with brain ischemic lesions by severity and location
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704651/
https://www.ncbi.nlm.nih.gov/pubmed/31439027
http://dx.doi.org/10.1186/s13293-019-0254-6
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