Liquid Biopsy in Malignant Pleural Mesothelioma: State of the Art, Pitfalls, and Perspectives

Malignant pleural mesothelioma (MPM) is an aggressive tumor linked to asbestos exposure. Although the risk factors for MPM are well-known, the majority of MPM patients are diagnosed at an advanced stage and have a very poor prognosis. Circulating biomarkers for early diagnosis remain to be identifie...

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Autores principales: Cavallari, Ilaria, Urso, Loredana, Sharova, Evgeniya, Pasello, Giulia, Ciminale, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705182/
https://www.ncbi.nlm.nih.gov/pubmed/31475103
http://dx.doi.org/10.3389/fonc.2019.00740
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author Cavallari, Ilaria
Urso, Loredana
Sharova, Evgeniya
Pasello, Giulia
Ciminale, Vincenzo
author_facet Cavallari, Ilaria
Urso, Loredana
Sharova, Evgeniya
Pasello, Giulia
Ciminale, Vincenzo
author_sort Cavallari, Ilaria
collection PubMed
description Malignant pleural mesothelioma (MPM) is an aggressive tumor linked to asbestos exposure. Although the risk factors for MPM are well-known, the majority of MPM patients are diagnosed at an advanced stage and have a very poor prognosis. Circulating biomarkers for early diagnosis remain to be identified, and the current standard for MPM diagnosis relies on pleural biopsies. Robust non-invasive tests for the screening of asbestos-exposed subjects are therefore an important unmet clinical need. This review provides a critical summary of recent liquid biopsy-based studies aimed at discovering novel blood-based circulating biomarkers for the early diagnosis and prognostic stratification of MPM patients.
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spelling pubmed-67051822019-08-30 Liquid Biopsy in Malignant Pleural Mesothelioma: State of the Art, Pitfalls, and Perspectives Cavallari, Ilaria Urso, Loredana Sharova, Evgeniya Pasello, Giulia Ciminale, Vincenzo Front Oncol Oncology Malignant pleural mesothelioma (MPM) is an aggressive tumor linked to asbestos exposure. Although the risk factors for MPM are well-known, the majority of MPM patients are diagnosed at an advanced stage and have a very poor prognosis. Circulating biomarkers for early diagnosis remain to be identified, and the current standard for MPM diagnosis relies on pleural biopsies. Robust non-invasive tests for the screening of asbestos-exposed subjects are therefore an important unmet clinical need. This review provides a critical summary of recent liquid biopsy-based studies aimed at discovering novel blood-based circulating biomarkers for the early diagnosis and prognostic stratification of MPM patients. Frontiers Media S.A. 2019-08-14 /pmc/articles/PMC6705182/ /pubmed/31475103 http://dx.doi.org/10.3389/fonc.2019.00740 Text en Copyright © 2019 Cavallari, Urso, Sharova, Pasello and Ciminale. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Cavallari, Ilaria
Urso, Loredana
Sharova, Evgeniya
Pasello, Giulia
Ciminale, Vincenzo
Liquid Biopsy in Malignant Pleural Mesothelioma: State of the Art, Pitfalls, and Perspectives
title Liquid Biopsy in Malignant Pleural Mesothelioma: State of the Art, Pitfalls, and Perspectives
title_full Liquid Biopsy in Malignant Pleural Mesothelioma: State of the Art, Pitfalls, and Perspectives
title_fullStr Liquid Biopsy in Malignant Pleural Mesothelioma: State of the Art, Pitfalls, and Perspectives
title_full_unstemmed Liquid Biopsy in Malignant Pleural Mesothelioma: State of the Art, Pitfalls, and Perspectives
title_short Liquid Biopsy in Malignant Pleural Mesothelioma: State of the Art, Pitfalls, and Perspectives
title_sort liquid biopsy in malignant pleural mesothelioma: state of the art, pitfalls, and perspectives
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705182/
https://www.ncbi.nlm.nih.gov/pubmed/31475103
http://dx.doi.org/10.3389/fonc.2019.00740
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