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Using Small-Angle Scattering Data and Parametric Machine Learning to Optimize Force Field Parameters for Intrinsically Disordered Proteins

Intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) play important roles in many aspects of normal cell physiology, such as signal transduction and transcription, as well as pathological states, including Alzheimer's, Parkinson's, and Huntingt...

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Detalles Bibliográficos
Autores principales:	Demerdash, Omar, Shrestha, Utsab R., Petridis, Loukas, Smith, Jeremy C., Mitchell, Julie C., Ramanathan, Arvind
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705226/ https://www.ncbi.nlm.nih.gov/pubmed/31475155 http://dx.doi.org/10.3389/fmolb.2019.00064

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