Bioceramic cement in the filling of bone defects in rats

PURPOSE: To evaluate PBS(®)MCIMMO cement in the filling of bone defects. METHODS: Thirty-six adult male Wistar rats were divided into three groups of twelve individuals each (group 1, group 2 and group 3). In all groups, a bone failure in the femur was induced, 2.0 mm wide and 7.0 mm deep. In group 1, the PBS(®)MCIMMO cement was applied to the bone defect produced and a titanium implant (CONNECTION(®)) 1.5 mm thick and 6 mm long was installed. In group 2, only the PBS(®) CIMMO cement was installed. In group 3, only bone failure was performed. Kruskal Wallis tests were performed to compare the mean area among the three groups. RESULTS: In all comparisons, significance was observed for group 2 (p = 0.0014–0.0026). CONCLUSION: The PBS(®)CIMMO cement induced bone neoformation, and integration between the newly formed bone, cement, and implant was observed.