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Intravascular Large B-Cell Lymphoma Presenting with Hypoxemia without any Abnormalities on Standard Imaging Studies
Patient: Female, 75 Final Diagnosis: Intravascular lerge B-cell lymphoma Symptoms: Dyspnea Medication: — Clinical Procedure: — Specialty: Hematology OBJECTIVE: Rare disease BACKGROUND: Intravascular large B-cell lymphoma (IVLBCL) is characteristically diagnosed by histological examination of biopsie...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705343/ https://www.ncbi.nlm.nih.gov/pubmed/31409762 http://dx.doi.org/10.12659/AJCR.916877 |
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author | Tokushima, Midori Katsuki, Naoko E. Tago, Masaki Yamashita, Shu-ichi |
author_facet | Tokushima, Midori Katsuki, Naoko E. Tago, Masaki Yamashita, Shu-ichi |
author_sort | Tokushima, Midori |
collection | PubMed |
description | Patient: Female, 75 Final Diagnosis: Intravascular lerge B-cell lymphoma Symptoms: Dyspnea Medication: — Clinical Procedure: — Specialty: Hematology OBJECTIVE: Rare disease BACKGROUND: Intravascular large B-cell lymphoma (IVLBCL) is characteristically diagnosed by histological examination of biopsies of bone marrow or randomly harvested skin specimens in the absence of any diagnostic abnormalities on imaging studies, including computed tomography (CT). In particular, diagnosis of IVLBCL with pulmonary manifestations is challenging, because even in patients with severe respiratory failure, there are rarely abnormalities on standard imaging studies. CASE REPORT: A 75-year-old female presented with fatigue, weight loss, and high fever with chills for 3 months. Blood examinations on her initial visit to her primary physician showed high concentrations of C-reactive protein, lactate dehydrogenase, and soluble interleukin-2 receptor. There were no abnormalities on imaging studies. She was subsequently admitted to our hospital because of development of dyspnea over time (4 months after symptom onset). Although she was suspected of having IVLBCL, repeated biopsies from bone marrow, skin, liver, and lung did not result in a diagnosis. Finally, a lung biopsy obtained by video-associated thoracic surgery (VATS) from the right lung base, where fluorine-18 fluorodeoxyglucose positron emission tomography had shown high uptake, resulted in a definite diagnosis of IVLBCL. CONCLUSIONS: Highly invasive procedures such as thoracoscopic lung resection may be required to diagnose IVLBCL with pulmonary manifestations which can cause severe respiratory failure in the absence of any abnormalities on standard imaging studies. |
format | Online Article Text |
id | pubmed-6705343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67053432019-09-11 Intravascular Large B-Cell Lymphoma Presenting with Hypoxemia without any Abnormalities on Standard Imaging Studies Tokushima, Midori Katsuki, Naoko E. Tago, Masaki Yamashita, Shu-ichi Am J Case Rep Articles Patient: Female, 75 Final Diagnosis: Intravascular lerge B-cell lymphoma Symptoms: Dyspnea Medication: — Clinical Procedure: — Specialty: Hematology OBJECTIVE: Rare disease BACKGROUND: Intravascular large B-cell lymphoma (IVLBCL) is characteristically diagnosed by histological examination of biopsies of bone marrow or randomly harvested skin specimens in the absence of any diagnostic abnormalities on imaging studies, including computed tomography (CT). In particular, diagnosis of IVLBCL with pulmonary manifestations is challenging, because even in patients with severe respiratory failure, there are rarely abnormalities on standard imaging studies. CASE REPORT: A 75-year-old female presented with fatigue, weight loss, and high fever with chills for 3 months. Blood examinations on her initial visit to her primary physician showed high concentrations of C-reactive protein, lactate dehydrogenase, and soluble interleukin-2 receptor. There were no abnormalities on imaging studies. She was subsequently admitted to our hospital because of development of dyspnea over time (4 months after symptom onset). Although she was suspected of having IVLBCL, repeated biopsies from bone marrow, skin, liver, and lung did not result in a diagnosis. Finally, a lung biopsy obtained by video-associated thoracic surgery (VATS) from the right lung base, where fluorine-18 fluorodeoxyglucose positron emission tomography had shown high uptake, resulted in a definite diagnosis of IVLBCL. CONCLUSIONS: Highly invasive procedures such as thoracoscopic lung resection may be required to diagnose IVLBCL with pulmonary manifestations which can cause severe respiratory failure in the absence of any abnormalities on standard imaging studies. International Scientific Literature, Inc. 2019-08-14 /pmc/articles/PMC6705343/ /pubmed/31409762 http://dx.doi.org/10.12659/AJCR.916877 Text en © Am J Case Rep, 2019 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Articles Tokushima, Midori Katsuki, Naoko E. Tago, Masaki Yamashita, Shu-ichi Intravascular Large B-Cell Lymphoma Presenting with Hypoxemia without any Abnormalities on Standard Imaging Studies |
title | Intravascular Large B-Cell Lymphoma Presenting with Hypoxemia without any Abnormalities on Standard Imaging Studies |
title_full | Intravascular Large B-Cell Lymphoma Presenting with Hypoxemia without any Abnormalities on Standard Imaging Studies |
title_fullStr | Intravascular Large B-Cell Lymphoma Presenting with Hypoxemia without any Abnormalities on Standard Imaging Studies |
title_full_unstemmed | Intravascular Large B-Cell Lymphoma Presenting with Hypoxemia without any Abnormalities on Standard Imaging Studies |
title_short | Intravascular Large B-Cell Lymphoma Presenting with Hypoxemia without any Abnormalities on Standard Imaging Studies |
title_sort | intravascular large b-cell lymphoma presenting with hypoxemia without any abnormalities on standard imaging studies |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705343/ https://www.ncbi.nlm.nih.gov/pubmed/31409762 http://dx.doi.org/10.12659/AJCR.916877 |
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