DHS (Trans-4,4’-Dihydroxystilbene) Suppresses DNA Replication and Tumor Growth by Inhibiting RRM2 (Ribonucleotide Reductase Regulatory Subunit M2)

DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Since inhibition of DNA replication can lead to replication fork stalling, resulting in DNA damage and apoptotic death, inhibitors of DNA replication are commonly used in cancer chemotherapy. Ribonucle...

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Detalles Bibliográficos
Autores principales: Chen, Chi-Wei, Li, Yongming, Hu, Shuya, Zhou, Wei, Meng, Yunxiao, Li, Zongzhu, Zhang, Yi, Sun, Jing, Bo, Zhou, DePamphilis, Melvin L., Yen, Yun, Han, Zhiyong, Zhu, Wenge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705423/
https://www.ncbi.nlm.nih.gov/pubmed/30518875
http://dx.doi.org/10.1038/s41388-018-0584-6

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