Specific inter-domain interactions stabilize a compact HIV-1 Gag conformation

HIV-1 Gag is a large multidomain poly-protein with flexible unstructured linkers connecting its globular subdomains. It is compact when in solution but assumes an extended conformation when assembled within the immature HIV-1 virion. Here, we use molecular dynamics (MD) simulations to quantitatively...

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Detalles Bibliográficos
Autores principales: Lin, Chen, Mendoza-Espinosa, Paola, Rouzina, Ioulia, Guzmán, Orlando, Moreno-Razo, José Antonio, Francisco, Joseph S., Bruinsma, Robijn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705756/
https://www.ncbi.nlm.nih.gov/pubmed/31437199
http://dx.doi.org/10.1371/journal.pone.0221256

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