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Dietary zinc and the control of Streptococcus pneumoniae infection
Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impact of disease, the molecular basis for protection remains unclear. Streptococcus pneumoniae is a major cause of bacterial pneumonia, which is prevalent in regions of zinc...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705770/ https://www.ncbi.nlm.nih.gov/pubmed/31437249 http://dx.doi.org/10.1371/journal.ppat.1007957 |
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author | Eijkelkamp, Bart A. Morey, Jacqueline R. Neville, Stephanie L. Tan, Aimee Pederick, Victoria G. Cole, Nerida Singh, Prashina P. Ong, Cheryl-Lynn Y. Gonzalez de Vega, Raquel Clases, David Cunningham, Bliss A. Hughes, Catherine E. Comerford, Iain Brazel, Erin B. Whittall, Jonathan J. Plumptre, Charles D. McColl, Shaun R. Paton, James C. McEwan, Alastair G. Doble, Philip A. McDevitt, Christopher A. |
author_facet | Eijkelkamp, Bart A. Morey, Jacqueline R. Neville, Stephanie L. Tan, Aimee Pederick, Victoria G. Cole, Nerida Singh, Prashina P. Ong, Cheryl-Lynn Y. Gonzalez de Vega, Raquel Clases, David Cunningham, Bliss A. Hughes, Catherine E. Comerford, Iain Brazel, Erin B. Whittall, Jonathan J. Plumptre, Charles D. McColl, Shaun R. Paton, James C. McEwan, Alastair G. Doble, Philip A. McDevitt, Christopher A. |
author_sort | Eijkelkamp, Bart A. |
collection | PubMed |
description | Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impact of disease, the molecular basis for protection remains unclear. Streptococcus pneumoniae is a major cause of bacterial pneumonia, which is prevalent in regions of zinc deficiency. We report that dietary zinc levels dictate the outcome of S. pneumoniae infection in a murine model. Dietary zinc restriction impacts murine tissue zinc levels with distribution post-infection altered, and S. pneumoniae virulence and infection enhanced. Although the activation and infiltration of murine phagocytic cells was not affected by zinc restriction, their efficacy of bacterial control was compromised. S. pneumoniae was shown to be highly sensitive to zinc intoxication, with this process impaired in zinc restricted mice and isolated phagocytic cells. Collectively, these data show how dietary zinc deficiency increases sensitivity to S. pneumoniae infection while revealing a role for zinc as a component of host antimicrobial defences. |
format | Online Article Text |
id | pubmed-6705770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-67057702019-09-04 Dietary zinc and the control of Streptococcus pneumoniae infection Eijkelkamp, Bart A. Morey, Jacqueline R. Neville, Stephanie L. Tan, Aimee Pederick, Victoria G. Cole, Nerida Singh, Prashina P. Ong, Cheryl-Lynn Y. Gonzalez de Vega, Raquel Clases, David Cunningham, Bliss A. Hughes, Catherine E. Comerford, Iain Brazel, Erin B. Whittall, Jonathan J. Plumptre, Charles D. McColl, Shaun R. Paton, James C. McEwan, Alastair G. Doble, Philip A. McDevitt, Christopher A. PLoS Pathog Research Article Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impact of disease, the molecular basis for protection remains unclear. Streptococcus pneumoniae is a major cause of bacterial pneumonia, which is prevalent in regions of zinc deficiency. We report that dietary zinc levels dictate the outcome of S. pneumoniae infection in a murine model. Dietary zinc restriction impacts murine tissue zinc levels with distribution post-infection altered, and S. pneumoniae virulence and infection enhanced. Although the activation and infiltration of murine phagocytic cells was not affected by zinc restriction, their efficacy of bacterial control was compromised. S. pneumoniae was shown to be highly sensitive to zinc intoxication, with this process impaired in zinc restricted mice and isolated phagocytic cells. Collectively, these data show how dietary zinc deficiency increases sensitivity to S. pneumoniae infection while revealing a role for zinc as a component of host antimicrobial defences. Public Library of Science 2019-08-22 /pmc/articles/PMC6705770/ /pubmed/31437249 http://dx.doi.org/10.1371/journal.ppat.1007957 Text en © 2019 Eijkelkamp et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Eijkelkamp, Bart A. Morey, Jacqueline R. Neville, Stephanie L. Tan, Aimee Pederick, Victoria G. Cole, Nerida Singh, Prashina P. Ong, Cheryl-Lynn Y. Gonzalez de Vega, Raquel Clases, David Cunningham, Bliss A. Hughes, Catherine E. Comerford, Iain Brazel, Erin B. Whittall, Jonathan J. Plumptre, Charles D. McColl, Shaun R. Paton, James C. McEwan, Alastair G. Doble, Philip A. McDevitt, Christopher A. Dietary zinc and the control of Streptococcus pneumoniae infection |
title | Dietary zinc and the control of Streptococcus pneumoniae infection |
title_full | Dietary zinc and the control of Streptococcus pneumoniae infection |
title_fullStr | Dietary zinc and the control of Streptococcus pneumoniae infection |
title_full_unstemmed | Dietary zinc and the control of Streptococcus pneumoniae infection |
title_short | Dietary zinc and the control of Streptococcus pneumoniae infection |
title_sort | dietary zinc and the control of streptococcus pneumoniae infection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705770/ https://www.ncbi.nlm.nih.gov/pubmed/31437249 http://dx.doi.org/10.1371/journal.ppat.1007957 |
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