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Incidence and Neonatal Risk factors of Short Stature and Growth Hormone treatment in Japanese Preterm Infants Born Small for Gestational Age

Incidence and neonatal risk factors for short stature in preterm children born small for gestational age (SGA) have not been fully investigated in Japan. In this prospective study, infants born ≤32 weeks’ gestational age (GA) from 2004–2015 were enrolled and followed for 3 years. Incidence of short...

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Autores principales: Matsumoto, Masaaki, Nagano, Nobuhiko, Awano, Hiroyuki, Ohyama, Shohei, Fujioka, Kazumichi, Iwatani, Sota, Urakami, Tatsuhiko, Iijima, Kazumoto, Morioka, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706397/
https://www.ncbi.nlm.nih.gov/pubmed/31439925
http://dx.doi.org/10.1038/s41598-019-48785-y
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author Matsumoto, Masaaki
Nagano, Nobuhiko
Awano, Hiroyuki
Ohyama, Shohei
Fujioka, Kazumichi
Iwatani, Sota
Urakami, Tatsuhiko
Iijima, Kazumoto
Morioka, Ichiro
author_facet Matsumoto, Masaaki
Nagano, Nobuhiko
Awano, Hiroyuki
Ohyama, Shohei
Fujioka, Kazumichi
Iwatani, Sota
Urakami, Tatsuhiko
Iijima, Kazumoto
Morioka, Ichiro
author_sort Matsumoto, Masaaki
collection PubMed
description Incidence and neonatal risk factors for short stature in preterm children born small for gestational age (SGA) have not been fully investigated in Japan. In this prospective study, infants born ≤32 weeks’ gestational age (GA) from 2004–2015 were enrolled and followed for 3 years. Incidence of short children born SGA and short stature treated with growth hormone (GH) were investigated. Neonatal risk factors were analysed using univariate and multivariate analyses. GA cut-off value was determined using receiver operating characteristic (ROC) curve analyses. Of 604 infants born ≤32 weeks’ GA, 76 (13%) were SGA at birth. Twenty-seven infants (36%) developed short stature at age 2 and 14 infants (19%) received GH treatment at age 3. GA, birthweight, birth length, birth head circumference, and chronic lung disease at 36 weeks’ corrected GA were determined as risk factors by univariate analyses (p < 0.01). Multivariate analyses only revealed low GA as an independent risk factor. ROC curve analysis determined a cut-off value of 24 weeks’ GA. Nineteen percent of preterm SGA infants ≤32 weeks’ GA developed short stature treated with GH. A low GA at birth could be an early detection marker for short stature that requires GH treatment in preterm infants born SGA.
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spelling pubmed-67063972019-09-08 Incidence and Neonatal Risk factors of Short Stature and Growth Hormone treatment in Japanese Preterm Infants Born Small for Gestational Age Matsumoto, Masaaki Nagano, Nobuhiko Awano, Hiroyuki Ohyama, Shohei Fujioka, Kazumichi Iwatani, Sota Urakami, Tatsuhiko Iijima, Kazumoto Morioka, Ichiro Sci Rep Article Incidence and neonatal risk factors for short stature in preterm children born small for gestational age (SGA) have not been fully investigated in Japan. In this prospective study, infants born ≤32 weeks’ gestational age (GA) from 2004–2015 were enrolled and followed for 3 years. Incidence of short children born SGA and short stature treated with growth hormone (GH) were investigated. Neonatal risk factors were analysed using univariate and multivariate analyses. GA cut-off value was determined using receiver operating characteristic (ROC) curve analyses. Of 604 infants born ≤32 weeks’ GA, 76 (13%) were SGA at birth. Twenty-seven infants (36%) developed short stature at age 2 and 14 infants (19%) received GH treatment at age 3. GA, birthweight, birth length, birth head circumference, and chronic lung disease at 36 weeks’ corrected GA were determined as risk factors by univariate analyses (p < 0.01). Multivariate analyses only revealed low GA as an independent risk factor. ROC curve analysis determined a cut-off value of 24 weeks’ GA. Nineteen percent of preterm SGA infants ≤32 weeks’ GA developed short stature treated with GH. A low GA at birth could be an early detection marker for short stature that requires GH treatment in preterm infants born SGA. Nature Publishing Group UK 2019-08-22 /pmc/articles/PMC6706397/ /pubmed/31439925 http://dx.doi.org/10.1038/s41598-019-48785-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Matsumoto, Masaaki
Nagano, Nobuhiko
Awano, Hiroyuki
Ohyama, Shohei
Fujioka, Kazumichi
Iwatani, Sota
Urakami, Tatsuhiko
Iijima, Kazumoto
Morioka, Ichiro
Incidence and Neonatal Risk factors of Short Stature and Growth Hormone treatment in Japanese Preterm Infants Born Small for Gestational Age
title Incidence and Neonatal Risk factors of Short Stature and Growth Hormone treatment in Japanese Preterm Infants Born Small for Gestational Age
title_full Incidence and Neonatal Risk factors of Short Stature and Growth Hormone treatment in Japanese Preterm Infants Born Small for Gestational Age
title_fullStr Incidence and Neonatal Risk factors of Short Stature and Growth Hormone treatment in Japanese Preterm Infants Born Small for Gestational Age
title_full_unstemmed Incidence and Neonatal Risk factors of Short Stature and Growth Hormone treatment in Japanese Preterm Infants Born Small for Gestational Age
title_short Incidence and Neonatal Risk factors of Short Stature and Growth Hormone treatment in Japanese Preterm Infants Born Small for Gestational Age
title_sort incidence and neonatal risk factors of short stature and growth hormone treatment in japanese preterm infants born small for gestational age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706397/
https://www.ncbi.nlm.nih.gov/pubmed/31439925
http://dx.doi.org/10.1038/s41598-019-48785-y
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