GluA4-Targeted AAV Vectors Deliver Genes Selectively to Interneurons while Relying on the AAV Receptor for Entry

Selective gene delivery into subtypes of interneurons remains an important challenge in vector development. Adeno-associated virus (AAV) vector particles are especially promising for intracerebral injections. For cell entry, AAV2 particles are supposed to attach to heparan-sulfate proteoglycans (HSP...

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Detalles Bibliográficos
Autores principales: Hartmann, Jessica, Thalheimer, Frederic B., Höpfner, Felix, Kerzel, Thomas, Khodosevich, Konstantin, García-González, Diego, Monyer, Hannah, Diester, Ilka, Büning, Hildegard, Carette, Jan E., Fries, Pascal, Buchholz, Christian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706527/
https://www.ncbi.nlm.nih.gov/pubmed/31463334
http://dx.doi.org/10.1016/j.omtm.2019.07.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706527/
https://www.ncbi.nlm.nih.gov/pubmed/31463334
http://dx.doi.org/10.1016/j.omtm.2019.07.004

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