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Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins

Evolution is proposed to result, in part, from acquisition of new developmental programs. One such example is the appearance of the micromeres in a sea urchin that form by an asymmetric cell division at the 4(th) embryonic cleavage and function as a major signaling center in the embryo. Micromeres a...

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Autores principales: Poon, Jessica, Fries, Annaliese, Wessel, Gary M., Yajima, Mamiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706577/
https://www.ncbi.nlm.nih.gov/pubmed/31439829
http://dx.doi.org/10.1038/s41467-019-11560-8
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author Poon, Jessica
Fries, Annaliese
Wessel, Gary M.
Yajima, Mamiko
author_facet Poon, Jessica
Fries, Annaliese
Wessel, Gary M.
Yajima, Mamiko
author_sort Poon, Jessica
collection PubMed
description Evolution is proposed to result, in part, from acquisition of new developmental programs. One such example is the appearance of the micromeres in a sea urchin that form by an asymmetric cell division at the 4(th) embryonic cleavage and function as a major signaling center in the embryo. Micromeres are not present in other echinoderms and thus are  considered as a derived feature, yet its acquisition mechanism is unknown. Here, we report that the polarity factor AGS and its associated proteins are responsible for micromere formation. Evolutionary modifications of AGS protein seem to have provided the cortical recruitment and binding of AGS to the vegetal cortex, contributing to formation of micromeres in the sea urchins. Indeed, introduction of sea urchin AGS into the sea star embryo induces asymmetric cell divisions, suggesting that the molecular evolution of AGS protein is key in the transition of echinoderms to micromere formation and the current developmental style of sea urchins not seen in other echinoderms.
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spelling pubmed-67065772019-08-26 Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins Poon, Jessica Fries, Annaliese Wessel, Gary M. Yajima, Mamiko Nat Commun Article Evolution is proposed to result, in part, from acquisition of new developmental programs. One such example is the appearance of the micromeres in a sea urchin that form by an asymmetric cell division at the 4(th) embryonic cleavage and function as a major signaling center in the embryo. Micromeres are not present in other echinoderms and thus are  considered as a derived feature, yet its acquisition mechanism is unknown. Here, we report that the polarity factor AGS and its associated proteins are responsible for micromere formation. Evolutionary modifications of AGS protein seem to have provided the cortical recruitment and binding of AGS to the vegetal cortex, contributing to formation of micromeres in the sea urchins. Indeed, introduction of sea urchin AGS into the sea star embryo induces asymmetric cell divisions, suggesting that the molecular evolution of AGS protein is key in the transition of echinoderms to micromere formation and the current developmental style of sea urchins not seen in other echinoderms. Nature Publishing Group UK 2019-08-22 /pmc/articles/PMC6706577/ /pubmed/31439829 http://dx.doi.org/10.1038/s41467-019-11560-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Poon, Jessica
Fries, Annaliese
Wessel, Gary M.
Yajima, Mamiko
Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins
title Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins
title_full Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins
title_fullStr Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins
title_full_unstemmed Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins
title_short Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins
title_sort evolutionary modification of ags protein contributes to formation of micromeres in sea urchins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706577/
https://www.ncbi.nlm.nih.gov/pubmed/31439829
http://dx.doi.org/10.1038/s41467-019-11560-8
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