Influence of BRCA1 Germline Mutations in the Somatic Mutational Burden of Triple-Negative Breast Cancer

The majority of the hereditary triple-negative breast cancers (TNBCs) are associated with BRCA1 germline mutations. Nevertheless, the understanding of the role of BRCA1 deficiency in the TNBC tumorigenesis is poor. In this sense, we performed whole-exome sequencing of triplet samples (leucocyte, tum...

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Detalles Bibliográficos
Autores principales: Ferreira, Elisa Napolitano, Brianese, Rafael Canfield, de Almeida, Renan Valieris Bueno, Drummond, Rodrigo Duarte, de Souza, Jorge Estefano, da Silva, Israel Tojal, de Souza, Sandro José, Carraro, Dirce Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706625/
https://www.ncbi.nlm.nih.gov/pubmed/31419696
http://dx.doi.org/10.1016/j.tranon.2019.07.016

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