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Diastereoselective Synthesis of Potent Antimalarial Cis-β-lactam Agents

Fifteen novel β-lactams bearing N-ethyl tert-butyl carbamate group 5a-o and fifteen N-(2- aminoethyl) β-lactams 6a-o were synthesized by [2+2] ketene-imine cycloaddition reaction (Staudinger). The cycloaddition reaction was found to be totally diastereoselective leading exclusively to theformation o...

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Detalles Bibliográficos
Autores principales:	Jarrahpour, Aliasghar, Rostami, Maryam, Sinou, Véronique, Latour, Christine, Djouhri-Bouktab, Lamia, Michel Brunel, Jean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shaheed Beheshti University of Medical Sciences 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706723/ https://www.ncbi.nlm.nih.gov/pubmed/31531044 http://dx.doi.org/10.22037/ijpr.2017.2024

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