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Toxicity of Manganese Titanate on Rat Vital Organ Mitochondria
The TiO2, which is a main material in the field of photocatalytic reactions, includes rutile and anatase phase. Titanium dioxide has possessed notice due to its promising applications in the environmental photocatalytic degradation of pollutants of organic compound in waste water and utilization of...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shaheed Beheshti University of Medical Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706733/ https://www.ncbi.nlm.nih.gov/pubmed/31531055 http://dx.doi.org/10.22037/ijpr.2019.1100639 |
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author | Entezari, Maliheh Ghanbary, Fatemeh |
author_facet | Entezari, Maliheh Ghanbary, Fatemeh |
author_sort | Entezari, Maliheh |
collection | PubMed |
description | The TiO2, which is a main material in the field of photocatalytic reactions, includes rutile and anatase phase. Titanium dioxide has possessed notice due to its promising applications in the environmental photocatalytic degradation of pollutants of organic compound in waste water and utilization of solar energy. The nanosized manganese titanate (pyrophanite) MnTiO3 was collected by oxidation of Mn(OH)2 with TiO2 powder in cetyltrimethylammonium bromide (CTAB) micelle solutions and the calcinations of the produced powders. Therefore, it was decided to determine the Mechanistic mitochondria toxicity of nanoparticles towards liver, kidney, heart, and brain via new and reliable methods. Our results showed that nanoparticles induced mitochondria dysfunction via an increase in ROS production and membrane potential collapse, correlated to cytochrome c release. Also, increased disturbance in oxidative phosphorylation was also shown by the decrease in ATP. Recent studies have suggested that nanoparticles leading to cytosolic release of lysosomal content, and ultimately apoptosis. This study suggests that mitochondrial oxidative stress and impairment of oxidative phosphorylation in vital organ Mitochondria may play a key role in manganese titanate toxicity. |
format | Online Article Text |
id | pubmed-6706733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Shaheed Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-67067332019-09-17 Toxicity of Manganese Titanate on Rat Vital Organ Mitochondria Entezari, Maliheh Ghanbary, Fatemeh Iran J Pharm Res Original Article The TiO2, which is a main material in the field of photocatalytic reactions, includes rutile and anatase phase. Titanium dioxide has possessed notice due to its promising applications in the environmental photocatalytic degradation of pollutants of organic compound in waste water and utilization of solar energy. The nanosized manganese titanate (pyrophanite) MnTiO3 was collected by oxidation of Mn(OH)2 with TiO2 powder in cetyltrimethylammonium bromide (CTAB) micelle solutions and the calcinations of the produced powders. Therefore, it was decided to determine the Mechanistic mitochondria toxicity of nanoparticles towards liver, kidney, heart, and brain via new and reliable methods. Our results showed that nanoparticles induced mitochondria dysfunction via an increase in ROS production and membrane potential collapse, correlated to cytochrome c release. Also, increased disturbance in oxidative phosphorylation was also shown by the decrease in ATP. Recent studies have suggested that nanoparticles leading to cytosolic release of lysosomal content, and ultimately apoptosis. This study suggests that mitochondrial oxidative stress and impairment of oxidative phosphorylation in vital organ Mitochondria may play a key role in manganese titanate toxicity. Shaheed Beheshti University of Medical Sciences 2019 /pmc/articles/PMC6706733/ /pubmed/31531055 http://dx.doi.org/10.22037/ijpr.2019.1100639 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Entezari, Maliheh Ghanbary, Fatemeh Toxicity of Manganese Titanate on Rat Vital Organ Mitochondria |
title | Toxicity of Manganese Titanate on Rat Vital Organ Mitochondria |
title_full | Toxicity of Manganese Titanate on Rat Vital Organ Mitochondria |
title_fullStr | Toxicity of Manganese Titanate on Rat Vital Organ Mitochondria |
title_full_unstemmed | Toxicity of Manganese Titanate on Rat Vital Organ Mitochondria |
title_short | Toxicity of Manganese Titanate on Rat Vital Organ Mitochondria |
title_sort | toxicity of manganese titanate on rat vital organ mitochondria |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706733/ https://www.ncbi.nlm.nih.gov/pubmed/31531055 http://dx.doi.org/10.22037/ijpr.2019.1100639 |
work_keys_str_mv | AT entezarimaliheh toxicityofmanganesetitanateonratvitalorganmitochondria AT ghanbaryfatemeh toxicityofmanganesetitanateonratvitalorganmitochondria |