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Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy
Sarcolemma-based focal adhesions (costameres) are a central hub for the cytoskeletal anchoring of myofibrils and mechano-regulated signaling. Here we report the time course of alterations in focal adhesion-associated signaling and fiber composition in rat soleus muscle after Achilles tenotomy. The r...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706776/ https://www.ncbi.nlm.nih.gov/pubmed/31463339 http://dx.doi.org/10.1016/j.dib.2019.103999 |
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author | Ferrié, Céline Kasper, Stephanie Wanivenhaus, Florian Flück, Martin |
author_facet | Ferrié, Céline Kasper, Stephanie Wanivenhaus, Florian Flück, Martin |
author_sort | Ferrié, Céline |
collection | PubMed |
description | Sarcolemma-based focal adhesions (costameres) are a central hub for the cytoskeletal anchoring of myofibrils and mechano-regulated signaling. Here we report the time course of alterations in focal adhesion-associated signaling and fiber composition in rat soleus muscle after Achilles tenotomy. The report includes data from tenotomized muscles and contralateral mock controls to expose whether muscle degeneration after tenotomy is due to the transection of the Achilles tendon, or circumjacent surgical manipulations of the tendon. With respect to the interpretation of the data regarding mechanistic implications of costamere-associated processes for surgical repair of the detached muscle-tendon complex the reader is referred to the accompanying research article ‘Focal adhesion kinase coordinates costamere-related JNK signaling with muscle fiber transformation after Achilles tenotomy and tendon reconstruction’ Ferrié et al., 2019. |
format | Online Article Text |
id | pubmed-6706776 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-67067762019-08-28 Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy Ferrié, Céline Kasper, Stephanie Wanivenhaus, Florian Flück, Martin Data Brief Biochemistry, Genetics and Molecular Biology Sarcolemma-based focal adhesions (costameres) are a central hub for the cytoskeletal anchoring of myofibrils and mechano-regulated signaling. Here we report the time course of alterations in focal adhesion-associated signaling and fiber composition in rat soleus muscle after Achilles tenotomy. The report includes data from tenotomized muscles and contralateral mock controls to expose whether muscle degeneration after tenotomy is due to the transection of the Achilles tendon, or circumjacent surgical manipulations of the tendon. With respect to the interpretation of the data regarding mechanistic implications of costamere-associated processes for surgical repair of the detached muscle-tendon complex the reader is referred to the accompanying research article ‘Focal adhesion kinase coordinates costamere-related JNK signaling with muscle fiber transformation after Achilles tenotomy and tendon reconstruction’ Ferrié et al., 2019. Elsevier 2019-07-10 /pmc/articles/PMC6706776/ /pubmed/31463339 http://dx.doi.org/10.1016/j.dib.2019.103999 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Biochemistry, Genetics and Molecular Biology Ferrié, Céline Kasper, Stephanie Wanivenhaus, Florian Flück, Martin Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy |
title | Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy |
title_full | Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy |
title_fullStr | Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy |
title_full_unstemmed | Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy |
title_short | Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy |
title_sort | time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy |
topic | Biochemistry, Genetics and Molecular Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706776/ https://www.ncbi.nlm.nih.gov/pubmed/31463339 http://dx.doi.org/10.1016/j.dib.2019.103999 |
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