Cargando…

Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy

Sarcolemma-based focal adhesions (costameres) are a central hub for the cytoskeletal anchoring of myofibrils and mechano-regulated signaling. Here we report the time course of alterations in focal adhesion-associated signaling and fiber composition in rat soleus muscle after Achilles tenotomy. The r...

Descripción completa

Detalles Bibliográficos
Autores principales: Ferrié, Céline, Kasper, Stephanie, Wanivenhaus, Florian, Flück, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706776/
https://www.ncbi.nlm.nih.gov/pubmed/31463339
http://dx.doi.org/10.1016/j.dib.2019.103999
_version_ 1783445755635171328
author Ferrié, Céline
Kasper, Stephanie
Wanivenhaus, Florian
Flück, Martin
author_facet Ferrié, Céline
Kasper, Stephanie
Wanivenhaus, Florian
Flück, Martin
author_sort Ferrié, Céline
collection PubMed
description Sarcolemma-based focal adhesions (costameres) are a central hub for the cytoskeletal anchoring of myofibrils and mechano-regulated signaling. Here we report the time course of alterations in focal adhesion-associated signaling and fiber composition in rat soleus muscle after Achilles tenotomy. The report includes data from tenotomized muscles and contralateral mock controls to expose whether muscle degeneration after tenotomy is due to the transection of the Achilles tendon, or circumjacent surgical manipulations of the tendon. With respect to the interpretation of the data regarding mechanistic implications of costamere-associated processes for surgical repair of the detached muscle-tendon complex the reader is referred to the accompanying research article ‘Focal adhesion kinase coordinates costamere-related JNK signaling with muscle fiber transformation after Achilles tenotomy and tendon reconstruction’ Ferrié et al., 2019.
format Online
Article
Text
id pubmed-6706776
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-67067762019-08-28 Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy Ferrié, Céline Kasper, Stephanie Wanivenhaus, Florian Flück, Martin Data Brief Biochemistry, Genetics and Molecular Biology Sarcolemma-based focal adhesions (costameres) are a central hub for the cytoskeletal anchoring of myofibrils and mechano-regulated signaling. Here we report the time course of alterations in focal adhesion-associated signaling and fiber composition in rat soleus muscle after Achilles tenotomy. The report includes data from tenotomized muscles and contralateral mock controls to expose whether muscle degeneration after tenotomy is due to the transection of the Achilles tendon, or circumjacent surgical manipulations of the tendon. With respect to the interpretation of the data regarding mechanistic implications of costamere-associated processes for surgical repair of the detached muscle-tendon complex the reader is referred to the accompanying research article ‘Focal adhesion kinase coordinates costamere-related JNK signaling with muscle fiber transformation after Achilles tenotomy and tendon reconstruction’ Ferrié et al., 2019. Elsevier 2019-07-10 /pmc/articles/PMC6706776/ /pubmed/31463339 http://dx.doi.org/10.1016/j.dib.2019.103999 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Biochemistry, Genetics and Molecular Biology
Ferrié, Céline
Kasper, Stephanie
Wanivenhaus, Florian
Flück, Martin
Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy
title Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy
title_full Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy
title_fullStr Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy
title_full_unstemmed Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy
title_short Time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy
title_sort time course of costamere-related alterations in focal adhesion signaling and composition of rat soleus muscle after achilles tenotomy
topic Biochemistry, Genetics and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706776/
https://www.ncbi.nlm.nih.gov/pubmed/31463339
http://dx.doi.org/10.1016/j.dib.2019.103999
work_keys_str_mv AT ferrieceline timecourseofcostamererelatedalterationsinfocaladhesionsignalingandcompositionofratsoleusmuscleafterachillestenotomy
AT kasperstephanie timecourseofcostamererelatedalterationsinfocaladhesionsignalingandcompositionofratsoleusmuscleafterachillestenotomy
AT wanivenhausflorian timecourseofcostamererelatedalterationsinfocaladhesionsignalingandcompositionofratsoleusmuscleafterachillestenotomy
AT fluckmartin timecourseofcostamererelatedalterationsinfocaladhesionsignalingandcompositionofratsoleusmuscleafterachillestenotomy