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A Simple Metal-Free Cyclization for the Synthesis of 4-Methylene-3-Substituted Quinazolinone and Quinazolinthione Derivatives: Experiment and Theory

A new series of 3-substituted 4-methylene-quinazolinthiones and 4-methylene-quinazolinones were synthesized in moderate to excellent yield through a simple reaction of 2-aminoacetophenones with isocyanates or isothiocyanates. The reaction shows good tolerance of many important functional groups in t...

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Detalles Bibliográficos
Autores principales:	Yan, Huihui, Xiao, Xu-Qiong, Hider, Robert C., Ma, Yongmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706782/ https://www.ncbi.nlm.nih.gov/pubmed/31475141 http://dx.doi.org/10.3389/fchem.2019.00584

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