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Identifying chemogenetic interactions from CRISPR screens with drugZ

BACKGROUND: Chemogenetic profiling enables the identification of gene mutations that enhance or suppress the activity of chemical compounds. This knowledge provides insights into drug mechanism of action, genetic vulnerabilities, and resistance mechanisms, all of which may help stratify patient popu...

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Detalles Bibliográficos
Autores principales:	Colic, Medina, Wang, Gang, Zimmermann, Michal, Mascall, Keith, McLaughlin, Megan, Bertolet, Lori, Lenoir, W. Frank, Moffat, Jason, Angers, Stephane, Durocher, Daniel, Hart, Traver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Software
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706933/ https://www.ncbi.nlm.nih.gov/pubmed/31439014 http://dx.doi.org/10.1186/s13073-019-0665-3

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