Cargando…
The Length of the Expressed 3′ UTR Is an Intermediate Molecular Phenotype Linking Genetic Variants to Complex Diseases
In the last decades, genome-wide association studies (GWAS) have uncovered tens of thousands of associations between common genetic variants and complex diseases. However, these statistical associations can rarely be interpreted functionally and mechanistically. As the majority of the disease-associ...
Autores principales: | Mariella, Elisa, Marotta, Federico, Grassi, Elena, Gilotto, Stefano, Provero, Paolo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707137/ https://www.ncbi.nlm.nih.gov/pubmed/31475030 http://dx.doi.org/10.3389/fgene.2019.00714 |
Ejemplares similares
-
The frequency of somatic mutations in cancer predicts the phenotypic relevance of germline mutations
por: Draetta, Edoardo Luigi, et al.
Publicado: (2023) -
Roar: detecting alternative polyadenylation with standard mRNA sequencing libraries
por: Grassi, Elena, et al.
Publicado: (2016) -
Shortening of 3′UTRs Correlates with Poor Prognosis in Breast and Lung Cancer
por: Lembo, Antonio, et al.
Publicado: (2012) -
To ERV Is Human: A Phenotype-Wide Scan Linking Polymorphic Human Endogenous Retrovirus-K Insertions to Complex Phenotypes
por: Wallace, Amelia D., et al.
Publicado: (2018) -
Identification of candidate regulatory sequences in mammalian 3' UTRs by statistical analysis of oligonucleotide distributions
por: Corà, Davide, et al.
Publicado: (2007)