Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits

Transcriptome-wide association studies integrate gene expression data with common risk variation to identify gene-trait associations. By incorporating epigenome data to estimate the functional importance of genetic variation on gene expression, we generate a small but significant improvement in the...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Wen, Voloudakis, Georgios, Rajagopal, Veera M., Readhead, Ben, Dudley, Joel T., Schadt, Eric E., Björkegren, Johan L. M., Kim, Yungil, Fullard, John F., Hoffman, Gabriel E., Roussos, Panos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707297/
https://www.ncbi.nlm.nih.gov/pubmed/31444360
http://dx.doi.org/10.1038/s41467-019-11874-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707297/
https://www.ncbi.nlm.nih.gov/pubmed/31444360
http://dx.doi.org/10.1038/s41467-019-11874-7

Ejemplares similares