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Adverse reactions of dimethyl sulfoxide in humans: a systematic review

Background: Dimethyl sulfoxide (DMSO) has been used for medical treatment and as a pharmacological agent in humans since the 1960s. Today, DMSO is used mostly for cryopreservation of stem cells, treatment of interstitial cystitis, and as a penetrating vehicle for various drugs. Many adverse reaction...

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Autores principales: Kollerup Madsen, Bennedikte, Hilscher, Maria, Zetner, Dennis, Rosenberg, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707402/
https://www.ncbi.nlm.nih.gov/pubmed/31489176
http://dx.doi.org/10.12688/f1000research.16642.2
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author Kollerup Madsen, Bennedikte
Hilscher, Maria
Zetner, Dennis
Rosenberg, Jacob
author_facet Kollerup Madsen, Bennedikte
Hilscher, Maria
Zetner, Dennis
Rosenberg, Jacob
author_sort Kollerup Madsen, Bennedikte
collection PubMed
description Background: Dimethyl sulfoxide (DMSO) has been used for medical treatment and as a pharmacological agent in humans since the 1960s. Today, DMSO is used mostly for cryopreservation of stem cells, treatment of interstitial cystitis, and as a penetrating vehicle for various drugs. Many adverse reactions have been described in relation to the use of DMSO, but to our knowledge, no overview of the existing literature has been made. Our aim was to conduct a systematic review describing the adverse reactions observed in humans in relation to the use of DMSO. Methods: This systematic review was reported according to the PRISMA-harms (Preferred Reporting Items for Systematic reviews and Meta-Analysis) guidelines. The primary outcome was any adverse reactions occurring in humans in relation to the use of DMSO. We included all original studies that reported adverse events due to the administration of DMSO, and that had a population of five or more. Results: We included a total of 109 studies. Gastrointestinal and skin reactions were the commonest reported adverse reactions to DMSO. Most reactions were transient without need for intervention. A relationship between the dose of DMSO given and the occurrence of adverse reactions was seen. Conclusions: DMSO may cause a variety of adverse reactions that are mostly transient and mild. The dose of DMSO plays an important role in the occurrence of adverse reactions. DMSO seems to be safe to use in small doses. Registration: PROSPERO CRD42018096117.
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spelling pubmed-67074022019-09-04 Adverse reactions of dimethyl sulfoxide in humans: a systematic review Kollerup Madsen, Bennedikte Hilscher, Maria Zetner, Dennis Rosenberg, Jacob F1000Res Systematic Review Background: Dimethyl sulfoxide (DMSO) has been used for medical treatment and as a pharmacological agent in humans since the 1960s. Today, DMSO is used mostly for cryopreservation of stem cells, treatment of interstitial cystitis, and as a penetrating vehicle for various drugs. Many adverse reactions have been described in relation to the use of DMSO, but to our knowledge, no overview of the existing literature has been made. Our aim was to conduct a systematic review describing the adverse reactions observed in humans in relation to the use of DMSO. Methods: This systematic review was reported according to the PRISMA-harms (Preferred Reporting Items for Systematic reviews and Meta-Analysis) guidelines. The primary outcome was any adverse reactions occurring in humans in relation to the use of DMSO. We included all original studies that reported adverse events due to the administration of DMSO, and that had a population of five or more. Results: We included a total of 109 studies. Gastrointestinal and skin reactions were the commonest reported adverse reactions to DMSO. Most reactions were transient without need for intervention. A relationship between the dose of DMSO given and the occurrence of adverse reactions was seen. Conclusions: DMSO may cause a variety of adverse reactions that are mostly transient and mild. The dose of DMSO plays an important role in the occurrence of adverse reactions. DMSO seems to be safe to use in small doses. Registration: PROSPERO CRD42018096117. F1000 Research Limited 2019-08-06 /pmc/articles/PMC6707402/ /pubmed/31489176 http://dx.doi.org/10.12688/f1000research.16642.2 Text en Copyright: © 2019 Kollerup Madsen B et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Systematic Review
Kollerup Madsen, Bennedikte
Hilscher, Maria
Zetner, Dennis
Rosenberg, Jacob
Adverse reactions of dimethyl sulfoxide in humans: a systematic review
title Adverse reactions of dimethyl sulfoxide in humans: a systematic review
title_full Adverse reactions of dimethyl sulfoxide in humans: a systematic review
title_fullStr Adverse reactions of dimethyl sulfoxide in humans: a systematic review
title_full_unstemmed Adverse reactions of dimethyl sulfoxide in humans: a systematic review
title_short Adverse reactions of dimethyl sulfoxide in humans: a systematic review
title_sort adverse reactions of dimethyl sulfoxide in humans: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707402/
https://www.ncbi.nlm.nih.gov/pubmed/31489176
http://dx.doi.org/10.12688/f1000research.16642.2
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