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In silico study of colchicine resistance molecular mechanisms caused by tubulin structural polymorphism
Starting from 1972, colchicine is known as the most useful drug for prevention of familial Mediterranean fever attacks. However, some patients do not respond to colchicine treatment, even taken in high doses. Despite the fact, that different hypotheses have been proposed, the molecular mechanisms of...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707608/ https://www.ncbi.nlm.nih.gov/pubmed/31442266 http://dx.doi.org/10.1371/journal.pone.0221532 |