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Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium

OBJECTIVE: To study the association of educational level and risk of death from all causes, cardiovascular disease (CVD) and cancer among Asian populations. DESIGN: A pooled analysis of 15 population-based cohort studies. SETTING AND PARTICIPANTS: 694 434 Asian individuals from 15 prospective cohort...

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Autores principales: Yang, Keming, Zhang, Ying, Saito, Eiko, Rahman, Md Shafiur, Gupta, Prakash Chandra, Sawada, Norie, Tamakoshi, Akiko, Gao, Yu-Tang, Koh, Woon-Puay, Shu, Xiao-Ou, Tsuji, Ichiro, Sadakane, Atsuko, Nagata, Chisato, You, San-Lin, Yuan, Jian-Min, Shin, Myung-Hee, Chen, Yu, Pan, Wen-Harn, Pednekar, Mangesh S, Tsugane, Shoichiro, Cai, Hui, Xiang, Yong-Bing, Ozasa, Kotaro, Tomata, Yasutake, Kanemura, Seiki, Sugawara, Yumi, Wada, Keiko, Wang, Renwei, Ahn, Yoon-Ok, Yoo, Keun-Young, Ahsan, Habibul, Chia, Kee Seng, Boffetta, Paolo, Kang, Daehee, Potter, John D, Inoue, Manami, Zheng, Wei, Nan, Hongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707688/
https://www.ncbi.nlm.nih.gov/pubmed/31444178
http://dx.doi.org/10.1136/bmjopen-2018-026225
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author Yang, Keming
Zhang, Ying
Saito, Eiko
Rahman, Md Shafiur
Gupta, Prakash Chandra
Sawada, Norie
Tamakoshi, Akiko
Gao, Yu-Tang
Koh, Woon-Puay
Shu, Xiao-Ou
Tsuji, Ichiro
Sadakane, Atsuko
Nagata, Chisato
You, San-Lin
Yuan, Jian-Min
Shin, Myung-Hee
Chen, Yu
Pan, Wen-Harn
Pednekar, Mangesh S
Tsugane, Shoichiro
Cai, Hui
Xiang, Yong-Bing
Ozasa, Kotaro
Tomata, Yasutake
Kanemura, Seiki
Sugawara, Yumi
Wada, Keiko
Wang, Renwei
Ahn, Yoon-Ok
Yoo, Keun-Young
Ahsan, Habibul
Chia, Kee Seng
Boffetta, Paolo
Kang, Daehee
Potter, John D
Inoue, Manami
Zheng, Wei
Nan, Hongmei
author_facet Yang, Keming
Zhang, Ying
Saito, Eiko
Rahman, Md Shafiur
Gupta, Prakash Chandra
Sawada, Norie
Tamakoshi, Akiko
Gao, Yu-Tang
Koh, Woon-Puay
Shu, Xiao-Ou
Tsuji, Ichiro
Sadakane, Atsuko
Nagata, Chisato
You, San-Lin
Yuan, Jian-Min
Shin, Myung-Hee
Chen, Yu
Pan, Wen-Harn
Pednekar, Mangesh S
Tsugane, Shoichiro
Cai, Hui
Xiang, Yong-Bing
Ozasa, Kotaro
Tomata, Yasutake
Kanemura, Seiki
Sugawara, Yumi
Wada, Keiko
Wang, Renwei
Ahn, Yoon-Ok
Yoo, Keun-Young
Ahsan, Habibul
Chia, Kee Seng
Boffetta, Paolo
Kang, Daehee
Potter, John D
Inoue, Manami
Zheng, Wei
Nan, Hongmei
author_sort Yang, Keming
collection PubMed
description OBJECTIVE: To study the association of educational level and risk of death from all causes, cardiovascular disease (CVD) and cancer among Asian populations. DESIGN: A pooled analysis of 15 population-based cohort studies. SETTING AND PARTICIPANTS: 694 434 Asian individuals from 15 prospective cohorts within the Asia Cohort Consortium. INTERVENTIONS: None. MAIN OUTCOME MEASURES: HRs and 95% CIs for all-cause mortality, as well as for CVD-specific mortality and cancer-specific mortality. RESULTS: A total of 694 434 participants (mean age at baseline=53.2 years) were included in the analysis. During a mean follow-up period of 12.5 years, 103 023 deaths were observed, among which 33 939 were due to cancer and 34 645 were due to CVD. Higher educational levels were significantly associated with lower risk of death from all causes compared with a low educational level (≤primary education); HRs and 95% CIs for secondary education, trade/technical education and ≥university education were 0.88 (0.85 to 0.92), 0.81 (0.73 to 0.90) and 0.71 (0.63 to 0.80), respectively (p(trend)=0.002). Similarly, HRs (95% CIs) were 0.93 (0.89 to 0.97), 0.86 (0.78 to 0.94) and 0.81 (0.73 to 0.89) for cancer death, and 0.88 (0.83 to 0.93), 0.77 (0.66 to 0.91) and 0.67 (0.58 to 0.77) for CVD death with increasing levels of education (both p(trend) <0.01). The pattern of the association among East Asians and South Asians was similar compared with ≤primary education; HR (95% CI) for all-cause mortality associated with ≥university education was 0.72 (0.63 to 0.81) among 539 724 East Asians (Chinese, Japanese and Korean) and 0.61 (0.54 to 0.69) among 154 710 South Asians (Indians and Bangladeshis). CONCLUSION: Higher educational level was associated with substantially lower risk of death among Asian populations.
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spelling pubmed-67076882019-09-06 Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium Yang, Keming Zhang, Ying Saito, Eiko Rahman, Md Shafiur Gupta, Prakash Chandra Sawada, Norie Tamakoshi, Akiko Gao, Yu-Tang Koh, Woon-Puay Shu, Xiao-Ou Tsuji, Ichiro Sadakane, Atsuko Nagata, Chisato You, San-Lin Yuan, Jian-Min Shin, Myung-Hee Chen, Yu Pan, Wen-Harn Pednekar, Mangesh S Tsugane, Shoichiro Cai, Hui Xiang, Yong-Bing Ozasa, Kotaro Tomata, Yasutake Kanemura, Seiki Sugawara, Yumi Wada, Keiko Wang, Renwei Ahn, Yoon-Ok Yoo, Keun-Young Ahsan, Habibul Chia, Kee Seng Boffetta, Paolo Kang, Daehee Potter, John D Inoue, Manami Zheng, Wei Nan, Hongmei BMJ Open Epidemiology OBJECTIVE: To study the association of educational level and risk of death from all causes, cardiovascular disease (CVD) and cancer among Asian populations. DESIGN: A pooled analysis of 15 population-based cohort studies. SETTING AND PARTICIPANTS: 694 434 Asian individuals from 15 prospective cohorts within the Asia Cohort Consortium. INTERVENTIONS: None. MAIN OUTCOME MEASURES: HRs and 95% CIs for all-cause mortality, as well as for CVD-specific mortality and cancer-specific mortality. RESULTS: A total of 694 434 participants (mean age at baseline=53.2 years) were included in the analysis. During a mean follow-up period of 12.5 years, 103 023 deaths were observed, among which 33 939 were due to cancer and 34 645 were due to CVD. Higher educational levels were significantly associated with lower risk of death from all causes compared with a low educational level (≤primary education); HRs and 95% CIs for secondary education, trade/technical education and ≥university education were 0.88 (0.85 to 0.92), 0.81 (0.73 to 0.90) and 0.71 (0.63 to 0.80), respectively (p(trend)=0.002). Similarly, HRs (95% CIs) were 0.93 (0.89 to 0.97), 0.86 (0.78 to 0.94) and 0.81 (0.73 to 0.89) for cancer death, and 0.88 (0.83 to 0.93), 0.77 (0.66 to 0.91) and 0.67 (0.58 to 0.77) for CVD death with increasing levels of education (both p(trend) <0.01). The pattern of the association among East Asians and South Asians was similar compared with ≤primary education; HR (95% CI) for all-cause mortality associated with ≥university education was 0.72 (0.63 to 0.81) among 539 724 East Asians (Chinese, Japanese and Korean) and 0.61 (0.54 to 0.69) among 154 710 South Asians (Indians and Bangladeshis). CONCLUSION: Higher educational level was associated with substantially lower risk of death among Asian populations. BMJ Publishing Group 2019-08-22 /pmc/articles/PMC6707688/ /pubmed/31444178 http://dx.doi.org/10.1136/bmjopen-2018-026225 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Epidemiology
Yang, Keming
Zhang, Ying
Saito, Eiko
Rahman, Md Shafiur
Gupta, Prakash Chandra
Sawada, Norie
Tamakoshi, Akiko
Gao, Yu-Tang
Koh, Woon-Puay
Shu, Xiao-Ou
Tsuji, Ichiro
Sadakane, Atsuko
Nagata, Chisato
You, San-Lin
Yuan, Jian-Min
Shin, Myung-Hee
Chen, Yu
Pan, Wen-Harn
Pednekar, Mangesh S
Tsugane, Shoichiro
Cai, Hui
Xiang, Yong-Bing
Ozasa, Kotaro
Tomata, Yasutake
Kanemura, Seiki
Sugawara, Yumi
Wada, Keiko
Wang, Renwei
Ahn, Yoon-Ok
Yoo, Keun-Young
Ahsan, Habibul
Chia, Kee Seng
Boffetta, Paolo
Kang, Daehee
Potter, John D
Inoue, Manami
Zheng, Wei
Nan, Hongmei
Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium
title Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium
title_full Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium
title_fullStr Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium
title_full_unstemmed Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium
title_short Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium
title_sort association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the asia cohort consortium
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707688/
https://www.ncbi.nlm.nih.gov/pubmed/31444178
http://dx.doi.org/10.1136/bmjopen-2018-026225
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