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Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction
Background and Aims: Radiation-induced intestinal injury occurred in application of radiotherapy for abdominal and pelvic cancers or in nuclear accidents. Radiation-induced enteritis may be considered an ideal model of gastrointestinal inflammation. The endothelium is a crucial component of inflamma...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707809/ https://www.ncbi.nlm.nih.gov/pubmed/31474856 http://dx.doi.org/10.3389/fphar.2019.00892 |
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author | Jang, Hyosun Lee, Janet Park, Sunhoo Kim, Joong Sun Shim, Sehwan Lee, Seung Bum Han, Sung-Honn Myung, Hyunwook Kim, Hyewon Jang, Won-Suk Lee, Sun-Joo Myung, Jae kyung |
author_facet | Jang, Hyosun Lee, Janet Park, Sunhoo Kim, Joong Sun Shim, Sehwan Lee, Seung Bum Han, Sung-Honn Myung, Hyunwook Kim, Hyewon Jang, Won-Suk Lee, Sun-Joo Myung, Jae kyung |
author_sort | Jang, Hyosun |
collection | PubMed |
description | Background and Aims: Radiation-induced intestinal injury occurred in application of radiotherapy for abdominal and pelvic cancers or in nuclear accidents. Radiation-induced enteritis may be considered an ideal model of gastrointestinal inflammation. The endothelium is a crucial component of inflammation, and the endothelial dysfunction following radiation exposure induces the intestinal proinflammatory response and progression of radiation enteritis. Baicalein (5,6,7-trihydroxyflavonoid) is a flavonoid from Scutellaria baicalensis used in oriental herbal medicine. Baicalein has been found to have multiple beneficial properties including antioxidant, anti-inflammatory, anti-allergic, and anti-cancer activities. Here, we investigated the therapeutic effects of baicalein on endothelial dysfunction in radiation-induced intestinal inflammation. Materials and Methods: We performed histological analysis, bacterial translocation, and intestinal permeability assays and also assessed infiltration of leukocytes and inflammatory cytokine expression using a mouse model of radiation-induced enteritis. In addition, to investigate the effect of baicalein in endothelial dysfunction, we analyzed endothelial-derived adherent molecules in human umbilical vein endothelial cells (HUVECs) and irradiated intestinal tissue. Results: Histological damage such as shortening of villi length and impaired intestinal crypt function was observed in the radiation-induced enteritis mouse model. Intestinal damage was attenuated in baicalein-treated groups with improvement of intestinal barrier function. Baicalein inhibited the expression of radiation-induced adherent molecules in HUVECs and intestine of irradiated mouse and decreased leukocyte infiltration in the radiation-induced enteritis. Conclusions: Baicalein could accelerate crypt regeneration via recovery of endothelial damage. Therefore, baicalein has a therapeutic effect on radiation-induced intestinal inflammation by attenuating endothelial damage. |
format | Online Article Text |
id | pubmed-6707809 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67078092019-08-30 Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction Jang, Hyosun Lee, Janet Park, Sunhoo Kim, Joong Sun Shim, Sehwan Lee, Seung Bum Han, Sung-Honn Myung, Hyunwook Kim, Hyewon Jang, Won-Suk Lee, Sun-Joo Myung, Jae kyung Front Pharmacol Pharmacology Background and Aims: Radiation-induced intestinal injury occurred in application of radiotherapy for abdominal and pelvic cancers or in nuclear accidents. Radiation-induced enteritis may be considered an ideal model of gastrointestinal inflammation. The endothelium is a crucial component of inflammation, and the endothelial dysfunction following radiation exposure induces the intestinal proinflammatory response and progression of radiation enteritis. Baicalein (5,6,7-trihydroxyflavonoid) is a flavonoid from Scutellaria baicalensis used in oriental herbal medicine. Baicalein has been found to have multiple beneficial properties including antioxidant, anti-inflammatory, anti-allergic, and anti-cancer activities. Here, we investigated the therapeutic effects of baicalein on endothelial dysfunction in radiation-induced intestinal inflammation. Materials and Methods: We performed histological analysis, bacterial translocation, and intestinal permeability assays and also assessed infiltration of leukocytes and inflammatory cytokine expression using a mouse model of radiation-induced enteritis. In addition, to investigate the effect of baicalein in endothelial dysfunction, we analyzed endothelial-derived adherent molecules in human umbilical vein endothelial cells (HUVECs) and irradiated intestinal tissue. Results: Histological damage such as shortening of villi length and impaired intestinal crypt function was observed in the radiation-induced enteritis mouse model. Intestinal damage was attenuated in baicalein-treated groups with improvement of intestinal barrier function. Baicalein inhibited the expression of radiation-induced adherent molecules in HUVECs and intestine of irradiated mouse and decreased leukocyte infiltration in the radiation-induced enteritis. Conclusions: Baicalein could accelerate crypt regeneration via recovery of endothelial damage. Therefore, baicalein has a therapeutic effect on radiation-induced intestinal inflammation by attenuating endothelial damage. Frontiers Media S.A. 2019-08-16 /pmc/articles/PMC6707809/ /pubmed/31474856 http://dx.doi.org/10.3389/fphar.2019.00892 Text en Copyright © 2019 Jang, Lee, Park, Kim, Shim, Lee, Han, Myung, Kim, Jang, Lee and Myung http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Jang, Hyosun Lee, Janet Park, Sunhoo Kim, Joong Sun Shim, Sehwan Lee, Seung Bum Han, Sung-Honn Myung, Hyunwook Kim, Hyewon Jang, Won-Suk Lee, Sun-Joo Myung, Jae kyung Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction |
title | Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction |
title_full | Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction |
title_fullStr | Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction |
title_full_unstemmed | Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction |
title_short | Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction |
title_sort | baicalein mitigates radiation-induced enteritis by improving endothelial dysfunction |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707809/ https://www.ncbi.nlm.nih.gov/pubmed/31474856 http://dx.doi.org/10.3389/fphar.2019.00892 |
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