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Functional Reprogramming of Regulatory T cells in the absence of Foxp3

Regulatory T cells (T(reg) cells) deficient in the transcription factor Foxp3 lack suppressor function and manifest a T effector (T(eff)) cell-like phenotype. We demonstrate that Foxp3 deficiency dysregulates metabolic checkpoint kinase mTORC2 signaling and gives rise to augmented aerobic glycolysis...

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Detalles Bibliográficos
Autores principales:	Charbonnier, Louis-Marie, Cui, Ye, Victor, Emmanuel, Harb, Hani, Lopez, David, Bleesing, Jack J, Garcia-Lloret, Maria I, Chen, Karin, Ozen, Ahmet, Carmeliet, Peter, Li, Ming O, Pellegrini, Matteo, Chatila, Talal A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707855/ https://www.ncbi.nlm.nih.gov/pubmed/31384057 http://dx.doi.org/10.1038/s41590-019-0442-x

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