Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing

An immunocompetent toddler came to medication attention with gastroenteritis, complicated by encephalopathy and hepatitis. Multiplexed testing using a polymerase chain reaction meningitis panel was positive for human herpesvirus 6 (HHV-6). Clinical correlation, quantitative HHV-6 polymerase chain re...

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Autores principales: Olson, Christina A., Dominguez, Samuel R., Miller, Steve, Chiu, Charles Y., Messacar, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707859/
https://www.ncbi.nlm.nih.gov/pubmed/31208781
http://dx.doi.org/10.1016/j.jpeds.2019.04.058
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author Olson, Christina A.
Dominguez, Samuel R.
Miller, Steve
Chiu, Charles Y.
Messacar, Kevin
author_facet Olson, Christina A.
Dominguez, Samuel R.
Miller, Steve
Chiu, Charles Y.
Messacar, Kevin
author_sort Olson, Christina A.
collection PubMed
description An immunocompetent toddler came to medication attention with gastroenteritis, complicated by encephalopathy and hepatitis. Multiplexed testing using a polymerase chain reaction meningitis panel was positive for human herpesvirus 6 (HHV-6). Clinical correlation, quantitative HHV-6 polymerase chain reaction, and metagenomic next-generation sequencing supported a likely diagnosis of primary HHV-6B infection.
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spelling pubmed-67078592020-03-25 Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing Olson, Christina A. Dominguez, Samuel R. Miller, Steve Chiu, Charles Y. Messacar, Kevin J Pediatr Article An immunocompetent toddler came to medication attention with gastroenteritis, complicated by encephalopathy and hepatitis. Multiplexed testing using a polymerase chain reaction meningitis panel was positive for human herpesvirus 6 (HHV-6). Clinical correlation, quantitative HHV-6 polymerase chain reaction, and metagenomic next-generation sequencing supported a likely diagnosis of primary HHV-6B infection. Elsevier Inc. 2019-09 2019-06-14 /pmc/articles/PMC6707859/ /pubmed/31208781 http://dx.doi.org/10.1016/j.jpeds.2019.04.058 Text en © 2019 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Olson, Christina A.
Dominguez, Samuel R.
Miller, Steve
Chiu, Charles Y.
Messacar, Kevin
Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing
title Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing
title_full Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing
title_fullStr Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing
title_full_unstemmed Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing
title_short Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing
title_sort gastroenteritis, hepatitis, encephalopathy, and human herpesvirus 6 detection in an immunocompetent child: benefits and risks of syndromic multiplex molecular panel testing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707859/
https://www.ncbi.nlm.nih.gov/pubmed/31208781
http://dx.doi.org/10.1016/j.jpeds.2019.04.058
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