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A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept

Bioprosthetic leaflets made from animal tissues are used in the majority of surgical and transcatheter cardiac valve replacements. This study develops a new surgical bioprosthesis, using porcine pericardial leaflets. Porcine pericardium was obtained from genetically engineered pigs with a mutation i...

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Autores principales: Rahmani, Benyamin, McGregor, Christopher, Byrne, Guerard, Burriesci, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707964/
https://www.ncbi.nlm.nih.gov/pubmed/30756359
http://dx.doi.org/10.1007/s12265-019-09868-3
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author Rahmani, Benyamin
McGregor, Christopher
Byrne, Guerard
Burriesci, Gaetano
author_facet Rahmani, Benyamin
McGregor, Christopher
Byrne, Guerard
Burriesci, Gaetano
author_sort Rahmani, Benyamin
collection PubMed
description Bioprosthetic leaflets made from animal tissues are used in the majority of surgical and transcatheter cardiac valve replacements. This study develops a new surgical bioprosthesis, using porcine pericardial leaflets. Porcine pericardium was obtained from genetically engineered pigs with a mutation in the GGTA-1 gene (GTKO) and fixed in 0.6% glutaraldehyde, and used to develop a new surgical valve design. The valves underwent in vitro hydrodynamic test in a pulse duplicator and high-cycled accelerated wear testing and were evaluated for acute haemodynamics and thrombogenicity in a juvenile sheep implant study for 48 h. The porcine surgical pericardial heart valves (pSPHVs) exhibited excellent hydrodynamics and reached 200 million cycles of in vitro durability, with no observable damage. Juvenile sheep implants demonstrated normal valve function with no acute thrombogenic response for either material. The pSPHV incorporates a minimalistic construction method using a tissue-to-tissue design to cover the stent. This new design is a proof of concept alternative to the use of bovine pericardium and synthetic fabric in surgical bioprosthetic heart valves.
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spelling pubmed-67079642019-09-06 A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept Rahmani, Benyamin McGregor, Christopher Byrne, Guerard Burriesci, Gaetano J Cardiovasc Transl Res Original Article Bioprosthetic leaflets made from animal tissues are used in the majority of surgical and transcatheter cardiac valve replacements. This study develops a new surgical bioprosthesis, using porcine pericardial leaflets. Porcine pericardium was obtained from genetically engineered pigs with a mutation in the GGTA-1 gene (GTKO) and fixed in 0.6% glutaraldehyde, and used to develop a new surgical valve design. The valves underwent in vitro hydrodynamic test in a pulse duplicator and high-cycled accelerated wear testing and were evaluated for acute haemodynamics and thrombogenicity in a juvenile sheep implant study for 48 h. The porcine surgical pericardial heart valves (pSPHVs) exhibited excellent hydrodynamics and reached 200 million cycles of in vitro durability, with no observable damage. Juvenile sheep implants demonstrated normal valve function with no acute thrombogenic response for either material. The pSPHV incorporates a minimalistic construction method using a tissue-to-tissue design to cover the stent. This new design is a proof of concept alternative to the use of bovine pericardium and synthetic fabric in surgical bioprosthetic heart valves. Springer US 2019-02-12 2019 /pmc/articles/PMC6707964/ /pubmed/30756359 http://dx.doi.org/10.1007/s12265-019-09868-3 Text en © The Author(s) 2019 OpenAccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Rahmani, Benyamin
McGregor, Christopher
Byrne, Guerard
Burriesci, Gaetano
A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept
title A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept
title_full A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept
title_fullStr A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept
title_full_unstemmed A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept
title_short A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept
title_sort durable porcine pericardial surgical bioprosthetic heart valve: a proof of concept
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707964/
https://www.ncbi.nlm.nih.gov/pubmed/30756359
http://dx.doi.org/10.1007/s12265-019-09868-3
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