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A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept
Bioprosthetic leaflets made from animal tissues are used in the majority of surgical and transcatheter cardiac valve replacements. This study develops a new surgical bioprosthesis, using porcine pericardial leaflets. Porcine pericardium was obtained from genetically engineered pigs with a mutation i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707964/ https://www.ncbi.nlm.nih.gov/pubmed/30756359 http://dx.doi.org/10.1007/s12265-019-09868-3 |
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author | Rahmani, Benyamin McGregor, Christopher Byrne, Guerard Burriesci, Gaetano |
author_facet | Rahmani, Benyamin McGregor, Christopher Byrne, Guerard Burriesci, Gaetano |
author_sort | Rahmani, Benyamin |
collection | PubMed |
description | Bioprosthetic leaflets made from animal tissues are used in the majority of surgical and transcatheter cardiac valve replacements. This study develops a new surgical bioprosthesis, using porcine pericardial leaflets. Porcine pericardium was obtained from genetically engineered pigs with a mutation in the GGTA-1 gene (GTKO) and fixed in 0.6% glutaraldehyde, and used to develop a new surgical valve design. The valves underwent in vitro hydrodynamic test in a pulse duplicator and high-cycled accelerated wear testing and were evaluated for acute haemodynamics and thrombogenicity in a juvenile sheep implant study for 48 h. The porcine surgical pericardial heart valves (pSPHVs) exhibited excellent hydrodynamics and reached 200 million cycles of in vitro durability, with no observable damage. Juvenile sheep implants demonstrated normal valve function with no acute thrombogenic response for either material. The pSPHV incorporates a minimalistic construction method using a tissue-to-tissue design to cover the stent. This new design is a proof of concept alternative to the use of bovine pericardium and synthetic fabric in surgical bioprosthetic heart valves. |
format | Online Article Text |
id | pubmed-6707964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-67079642019-09-06 A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept Rahmani, Benyamin McGregor, Christopher Byrne, Guerard Burriesci, Gaetano J Cardiovasc Transl Res Original Article Bioprosthetic leaflets made from animal tissues are used in the majority of surgical and transcatheter cardiac valve replacements. This study develops a new surgical bioprosthesis, using porcine pericardial leaflets. Porcine pericardium was obtained from genetically engineered pigs with a mutation in the GGTA-1 gene (GTKO) and fixed in 0.6% glutaraldehyde, and used to develop a new surgical valve design. The valves underwent in vitro hydrodynamic test in a pulse duplicator and high-cycled accelerated wear testing and were evaluated for acute haemodynamics and thrombogenicity in a juvenile sheep implant study for 48 h. The porcine surgical pericardial heart valves (pSPHVs) exhibited excellent hydrodynamics and reached 200 million cycles of in vitro durability, with no observable damage. Juvenile sheep implants demonstrated normal valve function with no acute thrombogenic response for either material. The pSPHV incorporates a minimalistic construction method using a tissue-to-tissue design to cover the stent. This new design is a proof of concept alternative to the use of bovine pericardium and synthetic fabric in surgical bioprosthetic heart valves. Springer US 2019-02-12 2019 /pmc/articles/PMC6707964/ /pubmed/30756359 http://dx.doi.org/10.1007/s12265-019-09868-3 Text en © The Author(s) 2019 OpenAccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Rahmani, Benyamin McGregor, Christopher Byrne, Guerard Burriesci, Gaetano A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept |
title | A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept |
title_full | A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept |
title_fullStr | A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept |
title_full_unstemmed | A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept |
title_short | A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept |
title_sort | durable porcine pericardial surgical bioprosthetic heart valve: a proof of concept |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707964/ https://www.ncbi.nlm.nih.gov/pubmed/30756359 http://dx.doi.org/10.1007/s12265-019-09868-3 |
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