Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Decellularized Allogenic Semitendinous Tendon Combined with Autologous Bone Marrow‐Derived Mesenchymal Stem Cells

As a regular adoptable material for anterior cruciate ligament (ACL) reconstruction, free tendon allograft exhibits unsatisfactory outcomes, such as retarded ligamentization and tendon–bone integration. The application of bone marrow‐derived mesenchymal stem cells (BMSCs), as well as a decellularize...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Wei, Xu, Jian, Dong, Shikui, Xie, Guoming, Yang, Shuanghui, Huangfu, Xiaoqiao, Li, Xiaoxi, Zhang, Yang, Shen, Peng, Yan, Zhaowen, Liu, Haifeng, Deng, Zhenhan, Zhao, Jinzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Tissue Engineering and Regenerative Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708071/
https://www.ncbi.nlm.nih.gov/pubmed/31077578
http://dx.doi.org/10.1002/sctm.18-0132
Descripción
Sumario:As a regular adoptable material for anterior cruciate ligament (ACL) reconstruction, free tendon allograft exhibits unsatisfactory outcomes, such as retarded ligamentization and tendon–bone integration. The application of bone marrow‐derived mesenchymal stem cells (BMSCs), as well as a decellularized free tendon allograft developed by our group, was proven to be effective in improving ACL reconstruction results. This study aimed to investigate the efficacy and feasibility of decellularized allogenic semitendinous tendon (ST) combined with autologous BMSCs used as a substitute to free tendon allograft in a rabbit model. This study finally shows that the decellularized allogenic ST combined with autologous BMSCs could significantly improve ACL reconstruction results compared with allograft. stem cells translational medicine 2019;8:971&982

Ejemplares similares