Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Decellularized Allogenic Semitendinous Tendon Combined with Autologous Bone Marrow‐Derived Mesenchymal Stem Cells

As a regular adoptable material for anterior cruciate ligament (ACL) reconstruction, free tendon allograft exhibits unsatisfactory outcomes, such as retarded ligamentization and tendon–bone integration. The application of bone marrow‐derived mesenchymal stem cells (BMSCs), as well as a decellularize...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Wei, Xu, Jian, Dong, Shikui, Xie, Guoming, Yang, Shuanghui, Huangfu, Xiaoqiao, Li, Xiaoxi, Zhang, Yang, Shen, Peng, Yan, Zhaowen, Liu, Haifeng, Deng, Zhenhan, Zhao, Jinzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Tissue Engineering and Regenerative Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708071/
https://www.ncbi.nlm.nih.gov/pubmed/31077578
http://dx.doi.org/10.1002/sctm.18-0132
_version_ 1783445943940546560
author Lu, Wei
Xu, Jian
Dong, Shikui
Xie, Guoming
Yang, Shuanghui
Huangfu, Xiaoqiao
Li, Xiaoxi
Zhang, Yang
Shen, Peng
Yan, Zhaowen
Liu, Haifeng
Deng, Zhenhan
Zhao, Jinzhong
author_facet Lu, Wei
Xu, Jian
Dong, Shikui
Xie, Guoming
Yang, Shuanghui
Huangfu, Xiaoqiao
Li, Xiaoxi
Zhang, Yang
Shen, Peng
Yan, Zhaowen
Liu, Haifeng
Deng, Zhenhan
Zhao, Jinzhong
author_sort Lu, Wei
collection PubMed
description As a regular adoptable material for anterior cruciate ligament (ACL) reconstruction, free tendon allograft exhibits unsatisfactory outcomes, such as retarded ligamentization and tendon–bone integration. The application of bone marrow‐derived mesenchymal stem cells (BMSCs), as well as a decellularized free tendon allograft developed by our group, was proven to be effective in improving ACL reconstruction results. This study aimed to investigate the efficacy and feasibility of decellularized allogenic semitendinous tendon (ST) combined with autologous BMSCs used as a substitute to free tendon allograft in a rabbit model. This study finally shows that the decellularized allogenic ST combined with autologous BMSCs could significantly improve ACL reconstruction results compared with allograft. stem cells translational medicine 2019;8:971&982
format Online
Article
Text
id pubmed-6708071
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-67080712019-08-28 Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Decellularized Allogenic Semitendinous Tendon Combined with Autologous Bone Marrow‐Derived Mesenchymal Stem Cells Lu, Wei Xu, Jian Dong, Shikui Xie, Guoming Yang, Shuanghui Huangfu, Xiaoqiao Li, Xiaoxi Zhang, Yang Shen, Peng Yan, Zhaowen Liu, Haifeng Deng, Zhenhan Zhao, Jinzhong Stem Cells Transl Med Tissue Engineering and Regenerative Medicine As a regular adoptable material for anterior cruciate ligament (ACL) reconstruction, free tendon allograft exhibits unsatisfactory outcomes, such as retarded ligamentization and tendon–bone integration. The application of bone marrow‐derived mesenchymal stem cells (BMSCs), as well as a decellularized free tendon allograft developed by our group, was proven to be effective in improving ACL reconstruction results. This study aimed to investigate the efficacy and feasibility of decellularized allogenic semitendinous tendon (ST) combined with autologous BMSCs used as a substitute to free tendon allograft in a rabbit model. This study finally shows that the decellularized allogenic ST combined with autologous BMSCs could significantly improve ACL reconstruction results compared with allograft. stem cells translational medicine 2019;8:971&982 John Wiley & Sons, Inc. 2019-05-11 /pmc/articles/PMC6708071/ /pubmed/31077578 http://dx.doi.org/10.1002/sctm.18-0132 Text en © 2019 The Authors. stem cells translational medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Tissue Engineering and Regenerative Medicine
Lu, Wei
Xu, Jian
Dong, Shikui
Xie, Guoming
Yang, Shuanghui
Huangfu, Xiaoqiao
Li, Xiaoxi
Zhang, Yang
Shen, Peng
Yan, Zhaowen
Liu, Haifeng
Deng, Zhenhan
Zhao, Jinzhong
Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Decellularized Allogenic Semitendinous Tendon Combined with Autologous Bone Marrow‐Derived Mesenchymal Stem Cells
title Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Decellularized Allogenic Semitendinous Tendon Combined with Autologous Bone Marrow‐Derived Mesenchymal Stem Cells
title_full Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Decellularized Allogenic Semitendinous Tendon Combined with Autologous Bone Marrow‐Derived Mesenchymal Stem Cells
title_fullStr Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Decellularized Allogenic Semitendinous Tendon Combined with Autologous Bone Marrow‐Derived Mesenchymal Stem Cells
title_full_unstemmed Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Decellularized Allogenic Semitendinous Tendon Combined with Autologous Bone Marrow‐Derived Mesenchymal Stem Cells
title_short Anterior Cruciate Ligament Reconstruction in a Rabbit Model Using a Decellularized Allogenic Semitendinous Tendon Combined with Autologous Bone Marrow‐Derived Mesenchymal Stem Cells
title_sort anterior cruciate ligament reconstruction in a rabbit model using a decellularized allogenic semitendinous tendon combined with autologous bone marrow‐derived mesenchymal stem cells
topic Tissue Engineering and Regenerative Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708071/
https://www.ncbi.nlm.nih.gov/pubmed/31077578
http://dx.doi.org/10.1002/sctm.18-0132
work_keys_str_mv AT luwei anteriorcruciateligamentreconstructioninarabbitmodelusingadecellularizedallogenicsemitendinoustendoncombinedwithautologousbonemarrowderivedmesenchymalstemcells
AT xujian anteriorcruciateligamentreconstructioninarabbitmodelusingadecellularizedallogenicsemitendinoustendoncombinedwithautologousbonemarrowderivedmesenchymalstemcells
AT dongshikui anteriorcruciateligamentreconstructioninarabbitmodelusingadecellularizedallogenicsemitendinoustendoncombinedwithautologousbonemarrowderivedmesenchymalstemcells
AT xieguoming anteriorcruciateligamentreconstructioninarabbitmodelusingadecellularizedallogenicsemitendinoustendoncombinedwithautologousbonemarrowderivedmesenchymalstemcells
AT yangshuanghui anteriorcruciateligamentreconstructioninarabbitmodelusingadecellularizedallogenicsemitendinoustendoncombinedwithautologousbonemarrowderivedmesenchymalstemcells
AT huangfuxiaoqiao anteriorcruciateligamentreconstructioninarabbitmodelusingadecellularizedallogenicsemitendinoustendoncombinedwithautologousbonemarrowderivedmesenchymalstemcells
AT lixiaoxi anteriorcruciateligamentreconstructioninarabbitmodelusingadecellularizedallogenicsemitendinoustendoncombinedwithautologousbonemarrowderivedmesenchymalstemcells
AT zhangyang anteriorcruciateligamentreconstructioninarabbitmodelusingadecellularizedallogenicsemitendinoustendoncombinedwithautologousbonemarrowderivedmesenchymalstemcells
AT shenpeng anteriorcruciateligamentreconstructioninarabbitmodelusingadecellularizedallogenicsemitendinoustendoncombinedwithautologousbonemarrowderivedmesenchymalstemcells
AT yanzhaowen anteriorcruciateligamentreconstructioninarabbitmodelusingadecellularizedallogenicsemitendinoustendoncombinedwithautologousbonemarrowderivedmesenchymalstemcells
AT liuhaifeng anteriorcruciateligamentreconstructioninarabbitmodelusingadecellularizedallogenicsemitendinoustendoncombinedwithautologousbonemarrowderivedmesenchymalstemcells
AT dengzhenhan anteriorcruciateligamentreconstructioninarabbitmodelusingadecellularizedallogenicsemitendinoustendoncombinedwithautologousbonemarrowderivedmesenchymalstemcells
AT zhaojinzhong anteriorcruciateligamentreconstructioninarabbitmodelusingadecellularizedallogenicsemitendinoustendoncombinedwithautologousbonemarrowderivedmesenchymalstemcells

Ejemplares similares