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Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia

BACKGROUND: In this study, we aimed to analyze differences in plasma protein abundances between infants with and without bronchopulmonary dysplasia (BPD), to add new insights into a better understanding of the pathogenesis of this disease. METHODS: Cord and peripheral blood of neonates (≤ 30 weeks g...

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Autores principales: Zasada, Magdalena, Suski, Maciej, Bokiniec, Renata, Szwarc-Duma, Monika, Borszewska-Kornacka, Maria Katarzyna, Madej, Józef, Bujak-Giżycka, Beata, Madetko-Talowska, Anna, Revhaug, Cecilie, Baumbusch, Lars O., Saugstad, Ola D., Pietrzyk, Jacek Józef, Kwinta, Przemko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708124/
https://www.ncbi.nlm.nih.gov/pubmed/31445514
http://dx.doi.org/10.1186/s13052-019-0676-0
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author Zasada, Magdalena
Suski, Maciej
Bokiniec, Renata
Szwarc-Duma, Monika
Borszewska-Kornacka, Maria Katarzyna
Madej, Józef
Bujak-Giżycka, Beata
Madetko-Talowska, Anna
Revhaug, Cecilie
Baumbusch, Lars O.
Saugstad, Ola D.
Pietrzyk, Jacek Józef
Kwinta, Przemko
author_facet Zasada, Magdalena
Suski, Maciej
Bokiniec, Renata
Szwarc-Duma, Monika
Borszewska-Kornacka, Maria Katarzyna
Madej, Józef
Bujak-Giżycka, Beata
Madetko-Talowska, Anna
Revhaug, Cecilie
Baumbusch, Lars O.
Saugstad, Ola D.
Pietrzyk, Jacek Józef
Kwinta, Przemko
author_sort Zasada, Magdalena
collection PubMed
description BACKGROUND: In this study, we aimed to analyze differences in plasma protein abundances between infants with and without bronchopulmonary dysplasia (BPD), to add new insights into a better understanding of the pathogenesis of this disease. METHODS: Cord and peripheral blood of neonates (≤ 30 weeks gestational age) was drawn at birth and at the 36th postmenstrual week (36 PMA), respectively. Blood samples were retrospectively subdivided into BPD(+) and BPD(−) groups, according to the development of BPD. RESULTS: Children with BPD were characterized by decreased afamin, gelsolin and carboxypeptidase N subunit 2 levels in cord blood, and decreased galectin-3 binding protein and hemoglobin subunit gamma-1 levels, as well as an increased serotransferrin abundance in plasma at the 36 PMA. CONCLUSIONS: BPD development is associated with the plasma proteome changes in preterm infants, adding further evidence for the possible involvement of disturbances in vitamin E availability and impaired immunological processes in the progression of prematurity pulmonary complications. Moreover, it also points to the differences in proteins related to infection resistance and maintaining an adequate level of hematocrit in infants diagnosed with BPD.
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spelling pubmed-67081242019-08-28 Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia Zasada, Magdalena Suski, Maciej Bokiniec, Renata Szwarc-Duma, Monika Borszewska-Kornacka, Maria Katarzyna Madej, Józef Bujak-Giżycka, Beata Madetko-Talowska, Anna Revhaug, Cecilie Baumbusch, Lars O. Saugstad, Ola D. Pietrzyk, Jacek Józef Kwinta, Przemko Ital J Pediatr Research BACKGROUND: In this study, we aimed to analyze differences in plasma protein abundances between infants with and without bronchopulmonary dysplasia (BPD), to add new insights into a better understanding of the pathogenesis of this disease. METHODS: Cord and peripheral blood of neonates (≤ 30 weeks gestational age) was drawn at birth and at the 36th postmenstrual week (36 PMA), respectively. Blood samples were retrospectively subdivided into BPD(+) and BPD(−) groups, according to the development of BPD. RESULTS: Children with BPD were characterized by decreased afamin, gelsolin and carboxypeptidase N subunit 2 levels in cord blood, and decreased galectin-3 binding protein and hemoglobin subunit gamma-1 levels, as well as an increased serotransferrin abundance in plasma at the 36 PMA. CONCLUSIONS: BPD development is associated with the plasma proteome changes in preterm infants, adding further evidence for the possible involvement of disturbances in vitamin E availability and impaired immunological processes in the progression of prematurity pulmonary complications. Moreover, it also points to the differences in proteins related to infection resistance and maintaining an adequate level of hematocrit in infants diagnosed with BPD. BioMed Central 2019-08-24 /pmc/articles/PMC6708124/ /pubmed/31445514 http://dx.doi.org/10.1186/s13052-019-0676-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Zasada, Magdalena
Suski, Maciej
Bokiniec, Renata
Szwarc-Duma, Monika
Borszewska-Kornacka, Maria Katarzyna
Madej, Józef
Bujak-Giżycka, Beata
Madetko-Talowska, Anna
Revhaug, Cecilie
Baumbusch, Lars O.
Saugstad, Ola D.
Pietrzyk, Jacek Józef
Kwinta, Przemko
Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia
title Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia
title_full Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia
title_fullStr Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia
title_full_unstemmed Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia
title_short Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia
title_sort comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708124/
https://www.ncbi.nlm.nih.gov/pubmed/31445514
http://dx.doi.org/10.1186/s13052-019-0676-0
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