ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells

BACKGROUND: HER3/ErbB3 receptor deletion or blockade leads to tumor cell apoptosis, whereas its overexpression confers anti-cancer drug resistance through upregulation of protective mechanisms against apoptosis. We produced the anti-HER3 antibody 9F7-F11 that promotes HER3 ubiquitination and degrada...

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Detalles Bibliográficos
Autores principales: Le Clorennec, Christophe, Lazrek, Yassamine, Dubreuil, Olivier, Sampaio, Carla, Larbouret, Christel, Lanotte, Romain, Poul, Marie-Alix, Barret, Jean-Marc, Prost, Jean-François, Pèlegrin, André, Chardès, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708219/
https://www.ncbi.nlm.nih.gov/pubmed/31443721
http://dx.doi.org/10.1186/s12964-019-0413-8

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