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Clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma

BACKGROUND: The concept of head and neck cancers (HNSCC) having unique molecular signatures is well accepted but relating this to clinical presentation and disease behaviour is essential for patient benefit. Currently the clinical significance of HNSCC molecular subtypes is uncertain therefore perso...

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Autores principales: Qadir, Fatima, Lalli, Anand, Dar, Huma Habib, Hwang, Sungjae, Aldehlawi, Hebah, Ma, Hong, Dai, Haiyan, Waseem, Ahmad, Teh, Muy-Teck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708230/
https://www.ncbi.nlm.nih.gov/pubmed/31443700
http://dx.doi.org/10.1186/s12885-019-6059-5
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author Qadir, Fatima
Lalli, Anand
Dar, Huma Habib
Hwang, Sungjae
Aldehlawi, Hebah
Ma, Hong
Dai, Haiyan
Waseem, Ahmad
Teh, Muy-Teck
author_facet Qadir, Fatima
Lalli, Anand
Dar, Huma Habib
Hwang, Sungjae
Aldehlawi, Hebah
Ma, Hong
Dai, Haiyan
Waseem, Ahmad
Teh, Muy-Teck
author_sort Qadir, Fatima
collection PubMed
description BACKGROUND: The concept of head and neck cancers (HNSCC) having unique molecular signatures is well accepted but relating this to clinical presentation and disease behaviour is essential for patient benefit. Currently the clinical significance of HNSCC molecular subtypes is uncertain therefore personalisation of HNSCC treatment is not yet possible. METHODS: We performed meta-analysis on 8 microarray studies and identified six significantly up- (PLAU, FN1, CDCA5) and down-regulated (CRNN, CLEC3B and DUOX1) genes which were subsequently quantified by RT-qPCR in 100 HNSCC patient margin and core tumour samples. RESULTS: Retrospective correlation with sociodemographic and clinicopathological patient details identified two subgroups of opposing molecular signature (+q6 and -q6) that correlated to two recognised high-risk HNSCC populations in the UK. The +q6 group were older, male, and excessive alcohol users whilst the –q6 group were younger, female, paan-chewers and predominantly Bangladeshi. Additionally, all patients with tumour recurrence were in the latter subgroup. CONCLUSIONS: We provide the first evidence linking distinct molecular signatures in HNSCC with clinical presentations. Prospective trials are required to determine the correlation between these distinct genotypes and disease progression or treatment response. This is an important step towards the ultimate goal of improving outcomes by utilising personalised molecular-signature-guided treatments for HNSCC patients.
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spelling pubmed-67082302019-08-28 Clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma Qadir, Fatima Lalli, Anand Dar, Huma Habib Hwang, Sungjae Aldehlawi, Hebah Ma, Hong Dai, Haiyan Waseem, Ahmad Teh, Muy-Teck BMC Cancer Research Article BACKGROUND: The concept of head and neck cancers (HNSCC) having unique molecular signatures is well accepted but relating this to clinical presentation and disease behaviour is essential for patient benefit. Currently the clinical significance of HNSCC molecular subtypes is uncertain therefore personalisation of HNSCC treatment is not yet possible. METHODS: We performed meta-analysis on 8 microarray studies and identified six significantly up- (PLAU, FN1, CDCA5) and down-regulated (CRNN, CLEC3B and DUOX1) genes which were subsequently quantified by RT-qPCR in 100 HNSCC patient margin and core tumour samples. RESULTS: Retrospective correlation with sociodemographic and clinicopathological patient details identified two subgroups of opposing molecular signature (+q6 and -q6) that correlated to two recognised high-risk HNSCC populations in the UK. The +q6 group were older, male, and excessive alcohol users whilst the –q6 group were younger, female, paan-chewers and predominantly Bangladeshi. Additionally, all patients with tumour recurrence were in the latter subgroup. CONCLUSIONS: We provide the first evidence linking distinct molecular signatures in HNSCC with clinical presentations. Prospective trials are required to determine the correlation between these distinct genotypes and disease progression or treatment response. This is an important step towards the ultimate goal of improving outcomes by utilising personalised molecular-signature-guided treatments for HNSCC patients. BioMed Central 2019-08-23 /pmc/articles/PMC6708230/ /pubmed/31443700 http://dx.doi.org/10.1186/s12885-019-6059-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Qadir, Fatima
Lalli, Anand
Dar, Huma Habib
Hwang, Sungjae
Aldehlawi, Hebah
Ma, Hong
Dai, Haiyan
Waseem, Ahmad
Teh, Muy-Teck
Clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma
title Clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma
title_full Clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma
title_fullStr Clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma
title_full_unstemmed Clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma
title_short Clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma
title_sort clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708230/
https://www.ncbi.nlm.nih.gov/pubmed/31443700
http://dx.doi.org/10.1186/s12885-019-6059-5
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