Haploinsufficiency of NR3C1 drives glucocorticoid resistance in adult acute lymphoblastic leukemia cells by down-regulating the mitochondrial apoptosis axis, and is sensitive to Bcl-2 blockage

BACKGROUND: Relapse represents the leading cause of death in both child and adult patients with acute lymphoblastic leukemia (ALL). Development of chemo-resistance is ultimately responsible for treatment failure and relapse, therefore understanding the molecular basis underlying resistance is impera...

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Detalles Bibliográficos
Autores principales: Xiao, Haowen, Ding, Yingying, Gao, Yang, Wang, Li-Mengmeng, Wang, Huafang, Ding, Lijuan, Li, Xiaoqing, Yu, Xiaohong, Huang, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708234/
https://www.ncbi.nlm.nih.gov/pubmed/31462891
http://dx.doi.org/10.1186/s12935-019-0940-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708234/
https://www.ncbi.nlm.nih.gov/pubmed/31462891
http://dx.doi.org/10.1186/s12935-019-0940-9

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