Cargando…

Early and reversible changes to the hippocampal proteome in mice on a high-fat diet

BACKGROUND: The rise in global obesity makes it crucial to understand how diet drives obesity-related health conditions, such as premature cognitive decline and Alzheimer’s disease (AD). In AD hippocampal-dependent episodic memory is one of the first types of memory to be impaired. Previous studies...

Descripción completa

Detalles Bibliográficos
Autores principales:	McLean, Fiona H., Campbell, Fiona M., Sergi, Domenico, Grant, Christine, Morris, Amanda C., Hay, Elizabeth A., MacKenzie, Alasdair, Mayer, Claus D., Langston, Rosamund F., Williams, Lynda M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708244/ https://www.ncbi.nlm.nih.gov/pubmed/31462902 http://dx.doi.org/10.1186/s12986-019-0387-y

Ejemplares similares

A high-fat diet induces rapid changes in the mouse hypothalamic proteome
por: McLean, Fiona H., et al.
Publicado: (2019)

Rapid and reversible impairment of episodic memory by a high-fat diet in mice
por: McLean, Fiona H., et al.
Publicado: (2018)

Effects of dietary fat manipulation on cognition in mice and rats: protocol for a systematic review and meta-analysis
por: Ramage, Fiona J, et al.
Publicado: (2020)

SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice
por: Sergi, Domenico, et al.
Publicado: (2018)

Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I-deficient mice
por: McGillicuddy, Fiona C., et al.
Publicado: (2013)

Using the CRISPR/Cas9 system to understand neuropeptide biology and regulation
por: Hay, Elizabeth A., et al.
Publicado: (2017)

Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities
por: MacKenzie, Alasdair, et al.
Publicado: (2022)

Ontogeny of neural circuits underlying spatial memory in the rat
por: Ainge, James A., et al.
Publicado: (2012)

An Sp1 Modulated Regulatory Region Unique to Higher Primates Regulates Human Androgen Receptor Promoter Activity in Prostate Cancer Cells
por: Hay, Colin W., et al.
Publicado: (2015)

Reverse-ChIP Techniques for Identifying Locus-Specific Proteomes: A Key Tool in Unlocking the Cancer Regulome
por: MacKenzie, Tim M. G., et al.
Publicado: (2023)

“A Lot of People Are Struggling Privately. They Don’t Know Where to Go or They’re Not Sure of What to Do”: Frontline Service Provider Perspectives of the Nature of Household Food Insecurity in Scotland
por: Douglas, Flora, et al.
Publicado: (2018)

A High-Fat Diet Modifies Brain Neurotransmitter Profile and Hippocampal Proteome and Morphology in an IUGR Pig Model
por: Yeste, Natalia, et al.
Publicado: (2022)

The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high-fat diet
por: McEwan, Andrew, et al.
Publicado: (2020)

Restoration of hippocampal growth hormone reverses stress-induced hippocampal impairment
por: Vander Weele, Caitlin M., et al.
Publicado: (2013)

Developmental trajectory of episodic-like memory in rats
por: Asiminas, Antonis, et al.
Publicado: (2022)

Idiopathic and immune‐related pulmonary fibrosis: diagnostic and therapeutic challenges
por: McLean‐Tooke, Andrew, et al.
Publicado: (2019)

Regional Diversity in the Postsynaptic Proteome of the Mouse Brain
por: Roy, Marcia, et al.
Publicado: (2018)

Negative Regulation of the Androgen Receptor Gene Through a Primate-Specific Androgen Response Element Present in the 5′ UTR
por: Hay, Colin W., et al.
Publicado: (2014)

An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome
por: Hay, Elizabeth Anne, et al.
Publicado: (2017)

Disease‐associated polymorphisms within the conserved ECR1 enhancer differentially regulate the tissue‐specific activity of the cannabinoid‐1 receptor gene promoter; implications for cannabinoid pharmacogenetics
por: Hay, Elizabeth A., et al.
Publicado: (2019)

Evidence of uneven selective pressure on different subsets of the conserved human genome; implications for the significance of intronic and intergenic DNA
por: Davidson, Scott, et al.
Publicado: (2009)

Exploring the effects of polymorphisms on cis-regulatory signal transduction response
por: MacKenzie, Alasdair, et al.
Publicado: (2013)

Understanding the Dynamics of Gene Regulatory Systems; Characterisation and Clinical Relevance of cis-Regulatory Polymorphisms
por: Cowie, Philip, et al.
Publicado: (2013)

Perspective: Quality Versus Quantity; Is It Important to Assess the Role of Enhancers in Complex Disease from an In Vivo Perspective?
por: McEwan, Andrew R., et al.
Publicado: (2020)

Therapies to Slow, Stop, or Reverse Parkinson’s Disease
por: Foltynie, Tom, et al.
Publicado: (2018)

Short high fat diet triggers reversible and region specific effects in DCX(+) hippocampal immature neurons of adolescent male mice
por: Chiazza, Fausto, et al.
Publicado: (2021)

Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour
por: Hay, Elizabeth A., et al.
Publicado: (2019)

Hippocampal sclerosis, hippocampal neuron loss patterns and TDP‐43 in the aged population
por: Hokkanen, Suvi R. K., et al.
Publicado: (2017)

Hippocampal network hyperexcitability in young transgenic mice expressing human mutant alpha-synuclein
por: Tweedy, Clare, et al.
Publicado: (2021)

Linkage Disequilibrium and Evaluation of Genome-Wide Association Mapping Models in Tetraploid Potato
por: Sharma, Sanjeev Kumar, et al.
Publicado: (2018)

Coherence among Head Direction Cells before Eye Opening in Rat Pups
por: Bjerknes, Tale L., et al.
Publicado: (2015)

Proteomics as the final step in the functional metagenomics study of antimicrobial resistance
por: Fouhy, Fiona, et al.
Publicado: (2015)

Tapencarium (RZL-012) for Flank Fat Reduction: A Proof-of-Concept Study
por: Shridharani, Sachin M, et al.
Publicado: (2023)

Sustaining Patient Portal Continuous Use Intention and Enhancing Deep Structure Usage: Cognitive Dissonance Effects of Health Professional Encouragement and Security Concerns
por: Moqbel, Murad, et al.
Publicado: (2021)

Nascent Proteome Remodeling following Homeostatic Scaling at Hippocampal Synapses
por: Schanzenbächer, Christoph T., et al.
Publicado: (2016)

Proteomics profiling and pathway analysis of hippocampal aging in rhesus monkeys
por: Meng, Shu, et al.
Publicado: (2020)

Space Radiation-Induced Alterations in the Hippocampal Ubiquitin-Proteome System
por: Tidmore, Alyssa, et al.
Publicado: (2021)

Experience-Induced Remodeling of the Hippocampal Post-synaptic Proteome and Phosphoproteome
por: Heo, Seok, et al.
Publicado: (2023)

Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease
por: Arnoux, Isabelle, et al.
Publicado: (2018)

Lateral Entorhinal Cortex is Critical for Novel Object-Context Recognition
por: Wilson, David IG, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_37ekdn53t6njftasv6ubnclq8f